Fluoxetine, a selective serotonin reuptake inhibitor anti-depressant, causes undesirable side effects, including diarrhea and constipation. This research investigated the direct effects of fluoxetine at 0.001, 0.01, 0.1, 1, 10, 100 µM on duodenal proximal colonic tissue contractions. The investigation aimed to determine related mechanisms using an isolated mouse intestine model. Our study showe...

Introduction: Hemostasis mechanism involves blood coagulation as one of the step which is responsible for clot formation that restricts flow at site injury. By inhibiting cascade and reducing thrombus formation, several cardiovascular diseases (CVD) atherosclerosis can be prevented. Traditionally, Fagonia olivieri (zygophyllaceae) reported in treatment diabetes, coughs, purifier, cooling agent,...

Islamic Traditional Medicine (ITM) is a holistic system of medicine. Saffron (Crocus sativus) is one of the most famous plants cultivated in Iran and has a wide range of activities such as oxytocic, anti-carcinogenic, exhilarant, anti-depressant, and anti-asthma effects. In addition, saffron can increase the bioavailability and enhance absorption of other drugs. This study comprises a bibliogra...

Scorpion beta-toxins (beta-ScTxs) modify the activity of voltage-gated sodium (Nav) channels, thereby producing neurotoxic effects in diverse organisms. For this reason, beta-ScTxs are essential tools not only for discriminating among different channel sub-types but also for studying the mechanisms of channel gating and the structure-function relationship involved in this process. This review c...

Objective: The goal of this study is to find out how Fragaria Ananassa (strawberries) affects serotonin levels and mouse immobility duration during the different tests performed in mice evaluate antidepressant effects FragariaAnanassa. Methods: Antidepressant compared with Standard drugs by performing a Forced Swim Test Tail Suspension on albino mice. was administered two distinct groups animal...

the present study was designed to explore the anti-inflammatory effect of fluvoxamine, as a selective serotonin reuptake inhibitor (ssri) anti-depressant, on carrageenan-induced paw edema in more details. at first, fluvoxamine was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg kg-1) 30 min before the subplantar injection of carrageenan. fluvoxamine was also injected intra-peritoneally...

Background: Meibomian gland dysfunction (MGD) is an alteration in the function of meibomian glands, leading to decreased tear film stability. We aimed assess severity MGD and correlate it with various risk factors. Material methods: After taking permission from Institutional Ethical Committee, a prospective observational case-control study was conducted tertiary care centre on 100 consecutive p...

Now a days reprehensive food habits, erroneous life style, stress, environmental pollution etc are exerting awful effects on human beings. Stress has become an inevitable and most unwanted companion of civilization. It can be induced by several factors like changes extremes temperature, fear, anxiety, shock, grief, pain so on. When the individual is unable to cope with it, it induces number cli...