The aims of this study were to pilot universal antenatal HCV screening and to determine the true seroprevalence of HCV infection in an unselected antenatal population. A risk assessment questionnaire for HCV infection was applied to all women booking for antenatal care over a 1-year period. In addition the prevalence of anti-HCV antibody positive serology in this population was determined. Over...

Claudin-1 (CLDN1), a known host factor for hepatitis C virus (HCV) entry and cell-to-cell transmission, is a target molecule for inhibiting HCV infection. We previously developed four clones of mouse anti-CLDN1 monoclonal antibody (mAb) that prevented HCV infection in vitro. Two of these mAbs showed the highest antiviral activity. Here, we optimized the anti-CLDN1 mAbs as candidates for therape...

PURPOSE The present study was undertaken to determine the prevalence of HCV infection by antibody testing and HCV core antigen (HCVcAg) determination by ELISA in haemodialysis patients and to evaluate the HCV c Ag assay in the detection of HCV infected patients on haemodialysis. MATERIALS AND METHODS A total of 151 chronic renal failure patients on haemodialysis from May 2003 to October 2004 ...

BACKGROUND AND OBJECTIVES Hepatitis C Virus genotyping appears to be vital for predicting the response to antiviral therapy. The present study aimed to analyze the HCV genotypes in relation to persistence or clearance of the virus in residents of Hamadan Province, West-Iran. MATERIAL AND METHODS A total of 1159 recorded questionnaires of HCV infected people were evaluated in this prospective ...

Hepatitis C virus (HCV) is one of the major etiologic agents of chronic liver diseases. Early and effective screening test of HCV was developed since the virus was first identified in 1989. The screening test of HCV is antiHCV antibody test by immunoassays and the infection status is confirmed by recombinant immunoblot assay (RIBA) and nucleic acid testing of HCV. Anti-HCV test was firstly deve...

BACKGROUND Hepatitis C Virus (HCV) infection is diagnosed by antibody and RNA based methods. Patients with anti-HCV sample rate/cutoff rate (S/CO) ratios > 1 are reported as anti-HCV positive. RNA based methods are introduced to confirm positivity in seropositive samples. OBJECTIVES The current study aimed to assess relationship between S/CO rates and HCV-RNA levels in the laboratory to ident...

(1) BACKGROUND: There are limited data regarding human immunodeficiency virus (HIV) prevalence among hepatitis B virus (HBV) or hepatitis C virus (HCV) infected individuals. The aim of this cross-sectional study is to determine the prevalence of HBV and HCV infection among HIV individuals; (2) METHODS: A total of 409 patients (126 HBV+ and 283 HCV+) referred to the Brazilian Reference Laborator...

BACKGROUND/AIMS Most patients infected with hepatitis C virus (HCV) develop chronic infection and persistent viraemia. The immune mechanisms responsible for resolution of viraemia remain poorly understood. HCV specific humoral and cellular immune responses in patients with and without viraemia were investigated. METHODS In vitro T helper (TH) lymphocyte responses to structural and non-structu...

background: celiac disease is one of the malabsorption syndromes leads to growth and development retardation in children. there is no test lonely can definitely diagnose celiac; however, the collection of clinical findings, serologic tests, intestinal biopsy, and response to treatment may diagnose it. although diagnostic value is variable in different studies, they are used a non-invasive and a...

Background Evaluation of serological assays for hepatitis C (HCV) antibody screening is crucial ,as supplemental testing [Nucleic Acid Testing & Recombinant Immunoblot Assay (RIBA)] to verify anti-HCV reactive results is not widely practiced, due to limited availability and high cost. The current study was undertaken from January to May 2011, to evaluate 4 serological assays for HCV diagnosis, ...