WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devote...

Obtaining an in-depth understanding of the arms races between peptides comprising the innate immune response and bacterial pathogens is of fundamental interest and will inform the development of new antibacterial therapeutics. We investigated whether a whole organism view of antimicrobial peptide (AMP) challenge on Escherichia coli would provide a suitably sophisticated bacterial perspective on...

Several new pryrazolo-pyridazine derivatives (4a-h) were synthesized through multi-step synthesis and evaluated for their antimicrobial activities. In the first step, 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one (2) was prepared by reacting 4-(4-chlorophenyl)-4-oxobutanoic acid (1) with hydrazine hydrate. Then, aryl-aldehydes were reacted with 2 to furnish pyridazinone derivatives (3a-g). Finally...

objective(s):isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. on the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. the exact action of statins in ...

background and objectives: despite the vast production of new antibiotics in the last three decades, resistance to these drugs by microorganisms has increased and essential oils (eos) have been recognized to possess antimicrobial properties. methods:  in the present study, eos obtained from aerial parts of thymus vulgaris l., lavandula angustifolia mill., rosmarinus officinalis l. and mentha pi...

Enhanced Antibacterial study of engineered nanoparticles like: ZnO-NPs, Co-NPs, Au-NPs towards pathogenic Escherichia coli cells, and their investigation action against bacteria on the whole cells.

We describe the synthesis and antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(Nalpha-benzyloxycarbonyl-arginyl-leucylamido-1-[(E)-cinnamoylamido]-3-methylbutane, structurally based upon the inhibitory centre of the human cysteine protease inhibitor, cystatin C. The derivative, here called Cystapep 1, displayed antibacterial activity against several clinically impo...