Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and inexpensive high-throughput metabolic screen for novel antibiotics. This screen is based on a colorimetric assay of pH that identifies inhibitors of bacterial sugar fermentat...

BACKGROUND Bacterial Infections involving multi-drug resistant (MDR) phenotypes constitute a worldwide health concern. The present work was designed to assess the antibacterial properties of the methanol extracts of six medicinal plants (Anthocleista schweinfurthii, Nauclea latifolia, Boehmeria platyphylla, Caucalis melanantha, Erigeron floribundus and Zehneria scobra) and the effects of their ...

Many attempts have been made in the past to find chemotherapeutic agents active against the tubercle bacillus, and some agents alleged to have had such action, notably gold compounds, have had a considerable vogue. The discovery of the antibacterial action of the sulphonamides stimulated a search for compounds of related constitution having an action against the tubercle bacillus, and this resu...

BACKGROUND AND AIM: Bacterial plaque is a biofilm which is related to its host and its exact role is proved in caries and periodontal disease. These days people brush their teeth and use mouthwash. In this research the effect of Jaman solution (Hezar Co., Iran) was compared with Biotene mouth rinse in an in-vitro study.METHODS: Biotene mouth rinse (Laclede Co., US) contains 4 antibacterial enzy...

This study attempted to develop chitosan-based nanoparticles with increased stability and antibacterial activity. The chitosan/protamine hybrid nanoparticles were formed based on an ionic gelation method by mixing chitosan with protamine and subsequently cross-linking the mixtures with sodium tripolyphosphate (TPP). The effects of protamine on the chemical structures, physical properties, and a...

EVALUATION OF ANTIFUNGAL, ANTIBACTERIAL AND CYTOTOXIC EFFECTS SOME NEW DERIVATIVES SPIROOXYINDOLES

Background Staphylococcus aureus, methicillin-resistant and Escherichia coli, multidrug-resistant included in the list of antibiotic-resistant priority pathogens from WHO. As multidrug-resistant bacteria problem is increasing, it is necessary to probe new sources for identifying antimicrobial compounds. Medicinal plants represent a rich source of antimicrobial agents. One of the potential plant...

background and objective: early determination of antibacterial susceptibility increases the success of therapy, decreases unnecessary use of antibacterial agents and side-effects, and lowers the overall healthcare cost. materials and methods: a rapid colorimetric method for antibacterial susceptibility testing named qui-sensitest (inovative biotechnology organization, istanbul, turkey) was eval...