The validated method was applied for determination of residual solvents in certain film-coated marketed antibiotic formulation of ciprofloxacin, norfloxacin, pefloxacin, and ofloxacin. Twenty tablets each containing 500 mg, 400 mg, 400 mg, and 200 mg of ciprofloxacin, norfloxacin, pefloxacin, and ofloxacin, respectively were accurately weighed separately. The tablets were crushed in a separate ...

OBJECTIVE To determine the efficacy of intracapsular tonsillectomy using low-temperature plasma excision for improving the quality of the postoperative experience and for treating obstructive symptoms through 12 months postoperatively. DESIGN Prospective, randomized, controlled, single-blind study. SETTING Multiple private or institutional otolaryngology clinics. PATIENTS Fifty-five child...

BACKGROUND There are few studies of the pharmacokinetics of vancomycin and gentamicin in peritoneal dialysis (PD) patients and the influence of antibiotic concentrations on treatment outcome. Concerns about resistance to ceftazidime and potential of aminoglycoside toxicity make the choice of empiric antibiotic difficult. METHODS We retrospectively collected data from 613 patients on PD betwee...

BACKGROUND Recommended therapy duration for patients hospitalized with cellulitis is 10-14 days. Unnecessary use of antibiotics is one of the key factors driving resistance. Recent studies have shown that antibiotic therapy for cellulitis in outpatients can safely be shortened, despite residual inflammation. This study will compare in hospitalized patients the safety and effectiveness of shorte...

We have been examining the consequences of alternative modes of regulation of plasmid-borne, Tn10-encoded tetracycline resistance for the fitness of Escherichia coli. In a tetracycline-free environment, we measured the effects on fitness that were caused by (1) maximally induced expression of the resistance operon, (2) low-level constitutive expression of the resistance protein, (3) residual ex...

The release of gentamicin sulphate, sodium fusidate and diethanolamine fusidate from Palacos and CMW cements was studied using elution and serial plate transfer tests. Further tests were made to assay the drug remaining in the cement after antibacterial activity could no longer be detected by the above methods, to detect the sustained slow release of the residual drug, and to ascertain the mech...

The emergence of antibiotic-resistant bacteria may limit the effectiveness of antibiotics to treat bacterial contamination in fuel ethanol plants, and therefore, new antibacterial intervention methods and tools to test their application are needed. Using shake-flask cultures of Saccharomyces cerevisiae grown on saccharified corn mash and strains of lactic acid bacteria isolated from a dry-grind...

INTRODUCTION Pyolaryngocele is a very rare and serious complication of laryngocoele. It can present as deep spaces neck infection and mislead the diagnosis. Our aim is to attract the intention of the surgeon to this unusual entity and describe its clinical features. CASE SUMMARY We report a case of 45 years old male patient with five-week history of neck swelling, dysphonia, mild dyspnea and ...

Forty-one children with transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction underwent a Rastelli operation between 1971 and 1978. A homograft valve preserved in an antibiotic solution and extended with A dacron tube was the conduit of choice. Alternatively, conduits with porcine heterografts or valves constructed from calf pericardium w...

BACKGROUND Bacterial meningitis complicated by thrombosis, vasculitis, and aneurysm formation affecting both small and distal branches of cerebral vessels has been well described. Involvement of major cerebral vessels is rare and has only been documented late in the course of disease. CASE DESCRIPTION We describe the clinical and pathological findings in a young man who presented with pontine...