Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a between formaldehyde, benzyl amine, corresponding diterpene acid, and ethyl 2-isocyanoacetate. anticancer properties of compounds studied in vitro.

In recent years, a considerable number of structurally unique metabolites with biological and pharmacological activities have been isolated from the marine-derived fungi, such as polyketides, alkaloids, peptides, lactones, terpenoids and steroids. Some of these compounds have anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, antibiotic and cytotoxic properties. T...

Purpose The purpose of this study was to optimize a peptide (nABP284) that binds programmed cell death protein 1 (PD-1) by computer-based protocol in order increase its affinity. Then, aimed determine the inhibitory effects on cancer immune escape coculturing improving cytokine-induced killer (ICIK) cells with cells. Materials and Methods nABP284 PD-1 identified phage display technology our pre...

Gemcitabine (Gem) is used as a single agent or in combination with other anticancer agents to treat many types of solid tumors. However, it has many limitations such as a short plasma half-life, dose-limiting toxicities and drug resistance. Cell-penetrating peptides (CPPs) are short peptides which may deliver a large variety of cargo molecules into the cancerous cells. The current study was des...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

NK-lysin is an effector protein of the innate immune system and an important component of host protection. We isolated a SNP in the NK-lysin coding sequence among different chicken breeds. This A to G substitution at the position 271 nucleotide in the ORF results in an Asn (N) to Asp (D) amino acid alteration. We synthesized two 30-aa peptides (N29N and N29D) to compare the biological activity ...

Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922) and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell ...

      ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...

the biological activity and composition of the essential oil of sclerorhachis leptoclada rech. an endemic species from northeast of iran was studied. the essential oil was isolated from the aerial flowering parts of the plant and analyzed by gc and gc-ms. fifty-four compounds accounting for 95.9% of the total oil were characterized. the main constituents were (e)-nerolidol (14.5%), terpinen-4-o...

Most therapeutic agents used for treating brain malignancies face hindered transport through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these problems, we developed peptide conjugates of conventional experimental anticancer agents. SynB3 cell-penetrating derivatives were applied that can cross BBB. Tuftsin to target neuropilin-1 system selectivity better tumor Moreov...