Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in clinical settings. This study was aimed at characterizing the influence of arachidonyl-2'-chloroethylamide (ACEA-a selective cannabinoid CB1 receptor agonist) co-administered with phenylmethylsulfonyl fluoride (PMSF) on the anticonvulsant...

Carbamazepine (CBZ) is a drug used as anticonvulsant, especially in the treatment of epilepsy. For adequate control disease, must achieve blood concentrations, therefore, it very important to levels anticonvulsant drugs biological matrices with suitable analytical methods. A simple and fast liquid chromatographic method UV detection was developed validated for determination CBZ saliva. Chromato...

The enaminone methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate (E139) has anticonvulsant activities. It has been reported to have a better safety profile than some anticonvulsant drugs. Since some anticonvulsant drugs are used in the management of neuropathic pain, we evaluated the effects of E139 in rodent models of acute pain and paclitaxel-induced neuropathic pain. The react...

1. Godolphin, W., and Thoma, J., Quantitation of anticonvulsant drugs in serum by gas-liquid chromatography on the stationary phase SP-2510. C/in. Chem. 24, 483 (1978). 2. Hewitt, T. E., Sievers, D. Z., and Kessler, 0., Improved gas-chromatographic analysis for anticonvulsants. C/in. (‘hero. 24, 1854 (1978). 3. Bredesen, J. E., and .Johannesen, S. I., Simultaneous determination of some antiepil...

The aim of this study was to evaluate the effects of chronic astemizole and ketotifen administration on the anticonvulsant activity of antiepileptic drugs against maximal electroshock-induced convulsions in mice. Adverse effects were evaluated in the chimney test (motor performance) and passive avoidance task (long-term memory). Brain and plasma levels of antiepileptics were measured by immunof...

The propagation velocity of evoked muscle spikes was measured and normal values are presented. Carbamazepine, phenobarbitone, diazepam, and bromide-containing drugs were tested for their effect on conduction velocity of motor nerve and skeletal muscle fibres. All these drugs caused a decrease in spike propagation, both of motor nerves and skeletal muscle. After discussion of the probable mode a...

INTRODUCTION Benzothiazine derivatives are of significant interest due to their chemotherapeutic history. The title compounds 4-aryl-8-arylidene-5,6-dihydro-2-imino-6,6dimethyl-4H,7H-[3,1]benzothiazines (Scheme 1) have been synthesized from 2,6-diarylidene-4-methyl cyclohexanone (IIA-H), characterized by IR, HNMR and mass spectroscopy. The final compounds were investigated for their anticonvuls...

Keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity, a new series of 3-(2-(substitutedbenzylidene)hydrazinyl)-N-(substituted benzo[d]thiazol-2-yl)-propanamides were synthesized with aromatic hydrophobic aryl ring (A), NH-C=O as hydrogen bonding domain (HBD), nitrogen atom as electron donor (D), and phenyl as distal aryl ring (C). Synthesi...

All of the established antiepileptic drugs (AEDs) can produce cognitive side effects, which are increased with polypharmacy and with increasing dosage and anticonvulsant blood levels. However, cognitive side effects are usually modest for AED monotherapy with anticonvulsant blood levels within the standard therapeutic ranges. Further, these effects are offset in part by reduced seizure activity...

This study evaluated the potency and rapidity of some anticholinergics (atropine, biperiden, and trihexyphenidyl) and benzodiazepines (diazepam and midazolam) as an anticonvulsant treatment against seizures induced by six nerve agents (tabun, sarin, soman, cyclosarin, VR, and VX) and summarized the relationship between anticonvulsant activity and nerve agent-induced lethality and neuropathology...