The routine prophylactic use of anticonvulsants after brain surgery or in patients with brain metastasis without surgery seems to be a variable but common practice, regardless of whether the patient has a previous history of convulsions. Data on the risk of developing adverse drug reactions (ADRs) caused by diphenylhydantoin (DPH) used concomitantly during cranial radiotherapy is still conflict...

OBJECTIVE To analyze prescription strategies followed by rheumatologist specialized in FM treatment. METHODS A prospective, multicentric, 3-month follow-up study with two visits. The drug treatment was started following usual clinical practice conditions. Prescription of benzodiazepines, hypnotics, anticonvulsants and antidepressants were those mainly studied. Clinical evaluation was performe...

Patients with borderline personality disorder (BPD) are usually prescribed a variety of psychotropic drugs; however, none is recommended in the guidelines nor has any been approved for this indication. As data on drug prescriptions for BPD are sparse, cross-sectional data from the European Drug Safety Project AMSP were used to analyse drug prescriptions of 2195 in-patients with BPD between 2001...

Neuropathic pain, a form of chronic pain initiated and sustained by an insult to the peripheral or central nervous system, is a challenge to clinicians as it does not respond well to traditional pain therapies. However exact pathophysiology is not known but considering similarities between epilepsy models and in neuropathic pain models justify the rationale for use of anticonvulsant drugs in th...

Two patients with previous cerebral damage and seizures and three patients with acute inflammatory cerebral lesions developed status epilepticus. They were unresponsive to standard anticonvulsants, but anesthetic barbiturates (thiopental and pentobarbital) stopped the seizures promptly.

A group of patients presenting with seizures (focal or generalised) and abnormal CT scans who, on follow up, showed complete resolution of the CT scan changes, without any treatment other than anticonvulsants, are described.

Fifteen of 268 children admitted to a general medical ward suffered a definite or probable adverse drug reaction to their treatment. In 6 of these children the reactions were preventable. Anticonvulsants were the most common cause of an adverse reaction.