Antigen-specific T cell function is not understood in molecular terms. There is evidence that inducer T lymphocytes (Ly-1 cells) recognize antigen in association with products encoded by the I region of the major histocompatibility complex (1-3). By contrast, suppressive (Ly-2 +) lymphocytes and material extracted or derived from these ceils can bind free antigen (4). It is likely that a portio...

Antigen-specific T cell function is not understood in molecular terms. There is evidence that inducer T lymphocytes (Ly-1 cells) recognize antigen in association with products encoded by the I region of the major histocompatibility complex (1-3). By contrast, suppressive (Ly-2 +) lymphocytes and material extracted or derived from these ceils can bind free antigen (4). It is likely that a portio...

Antigen-specific T cell function is not understood in molecular terms. There is evidence that inducer T lymphocytes (Ly-1 cells) recognize antigen in association with products encoded by the I region of the major histocompatibility complex (1-3). By contrast, suppressive (Ly-2 +) lymphocytes and material extracted or derived from these ceils can bind free antigen (4). It is likely that a portio...

Allergic asthma is characterized by airway hyperresponsiveness and pulmonary eosinophilia, and may be mediated by T helper (Th) lymphocytes expressing a Th2 cytokine pattern. Interleukin (IL) 12 suppresses the expression of Th2 cytokines and their associated responses, including eosinophilia, serum immunoglobulin E, and mucosal mastocytosis. We have previously shown in a murine model that antig...

Antigen stimulation of cultured bone-marrow-derived mast cells sensitized with specific monoclonal IgE induced cell degranulation and paf-acether (paf; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) biosynthesis via the deacylation/acetylation (remodelling) pathway. Phorbol myristate acetate (PMA; 20-100 ng/ml) triggered only acetyltransferase activation, without concomitant lyso-paf (1-O-alky...

Objective The sensitivity of pancreatic juice cytology for intraductal papillary mucinous neoplasm is insufficient. We evaluated the usefulness of repeated pancreatic juice cytology via an endoscopic naso-pancreatic drainage tube combined with carcinoembryonic antigen level of pancreatic juice for the diagnosis of malignant intraductal papillary mucinous neoplasm. Methods Between April 2004 and...

OBJECTIVE To evaluate if prostate specific antigen test attains validity standards required for screening in view of recent prostate cancer screening trial results. DESIGN Case-control study nested in longitudinal cohort. SETTING Västerbotten Intervention Project cohort, Umeå, Sweden. PARTICIPANTS 540 cases and 1034 controls matched for age and date of blood draw. MAIN OUTCOME MEASURE V...

1. The human thymus-brain antigen, which corresponds to the murine (mouse or rat) Thy1 antigen complex, was isolated from brain after solubilization in deoxycholate by gel-permeation chromatography, wheat-germ-lectin affinity chromatography and ionexchange chromatography. 2. The isolated antigen is a glycoprotein displaying an apparent molecular weight of 26000-29000 in sodium dodecyl sulphate/...

Liposomes are widely investigated as vaccine delivery systems, but antigen loading efficiency can be low. Moreover, adsorbed may rapidly desorb under physiological conditions. Encapsulation of antigens overcomes the latter problem results in significant loss during preparation and purification liposomes. Here, we propose an alternative attachment method, based on a complementary heterodimeric c...