It's a great idea that you're looking into whether certain substances may have the potential for problematic or undesirable results! To answer your question ? it?s best to avoid mixing alcohol and antihistamines, as they both depress the central nervous system (CNS) [2], thereby impairing your ability to coordinate physical motor movements and remain awake and conscious. Additionally, alcohol d...

It's a great idea that you're looking into whether certain substances may have the potential for problematic or undesirable results! To answer your question ? it?s best to avoid mixing alcohol and antihistamines, as they both depress the central nervous system (CNS) [2], thereby impairing your ability to coordinate physical motor movements and remain awake and conscious. Additionally, alcohol d...

*Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Received: 09.08.2012; Accepted: 08.02.2014 Sir, I read with interest the case presented by Rajendiran C et al . enti t led:” Stroke after multiple bee sting” recently published in J Assoc Physicians India.1 The authors have presented a 25-yearold male referring to them after ...

Second generation H1 antihistamines are considered first-line therapy for allergic rhinitis and chronic idiopathic urticaria, largely because of their nonsedating effects. Evaluating pharmacokinetic and pharmacodynamic parameters and clinical efficacy of a drug is important, but models to predict clinical efficacy are lacking. Receptor occupancy (RO), a predictor for human pharmacodynamics and ...

The therapeutic index of a histamine-1 (H1)antihistamine is the benefit-to-risk ratio of the medication and defines the range of doses and plasma concentrations over which the drug is effective and safe. In allergic rhinoconjunctivitis and urticaria, although the efficacy profiles of currently available H1-antihistamines are similar, these agents differ greatly with regard to safety, and this c...