Topical retinoids, benzoyl peroxide, azelaic acid, and topical and oral antibiotics remain the milestone of treatment for mild to moderate acne vulgaris. Oral isotretinoin is useful for the treatment of severe nodular acne, treatment-resistant acne, and acne with a risk of physical or psychological scarring. Hormonal treatment in female acne is useful in resistant or late-onset acne. With incre...

The present investigation has evaluated the influence of aspirin, its constituents, and other nonsteroidal anti-inflammatory agents on the resistance of human platelets to aspiration into micropipettes. Aspirin increased the length of platelet extensions into the micropipette over the entire negative tension range of 0.04 to 0.40 dynes/cm after exposure to the drug in vitro or after ingestion o...

Acne is a disease of the pilosebaceous unit, involving abnormalities in sebum production, follicular epithelial desquamation, bacterial proliferation, and inflammation. The major classes of therapeutic agents are topical and systemic retinoids, antimicrobial agents, and systemic hormonal drugs. Combination therapy with a topical retinoid and an antibiotic can normalize follicular epithelial des...

According to WHO population-based data, cancer is a leading cause of mortality worldwide accounting for almost 13% of all death [1]. Among all types of cancer, lung, breast, colorectal, stomach, and prostate cancer is the underlying cause for the majority of cancer death. Hitherto, chemotherapy remains one of the therapeutic strategies adopted worldwide for the management of cancer either alone...

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Free fatty acids (FFAs) and acid synthesis (FAS) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, several types of cancer. Currently, treatment options are available for patients with these conditions. Due safety concerns, adverse effects, limited efficacy, low tolerability associated many medi...

Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of cells and/or lower airway structural cells. Several mediators can modulate these cells, particularly those belonging to chemokines (conventional atypical) family. There is emerging evidence for complex roles atypica...

Herein we describe the development of a new class of antimicrobial and anti-inflammatory peptidomimetics: cyclic lipo-α-AApeptides. They have potent and broad-spectrum antibacterial activity against a range of clinically relevant pathogens, including both multidrug-resistant Gram-positive and Gram-negative bacteria. Fluorescence microscopy suggests that cyclic lipo-α-AApeptides kill bacteria by...

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the most commonly prescribed agents for hypercholesterolemia and have revolutionized the management of hyperlipidemia and the area of cardiovascular risk reduction. However, recent data suggest that their effects go well beyond the lipid lowering seen with long-term use and may include acute antiinflammatory activity, ...