OBJECTIVES Buruli ulcer (BU) is a tropical skin disease caused by infection with Mycobacterium ulcerans, which is currently treated with 8 weeks of streptomycin and rifampicin. The evidence to treat BU for a duration of 8 weeks is limited; a recent retrospective study from Australia suggested that a shorter course of antimicrobial therapy might be equally effective. We studied the outcomes of B...

BACKGROUND Factors capable of impacting hospital mortality in patients with septic shock remain uncertain. Our objective was to identify predictors of hospital mortality among patients who received appropriate antimicrobial therapy for bacteremic septic shock after accounting for severity of illness, resuscitation status, and processes of care. METHODS We conducted a secondary subgroup analys...

Current research suggests that combination antimicrobial therapy where a given pathogen is covered by two or more antibiotics with differing antimicrobial mechanisms may be useful in a subset of critically ill patients, particularly those with septic shock. This paper elucidates the circumstances under which combination therapy may be useful by reinforcing the observation that beneficial effect...

Antimicrobial therapy is the standard of care for the unusual man with true chronic bacterial prostatitis but does not have much of a role in the treatment of men with nonbacterial prostatitis. The fluoroquinolone antibiotics given for 2 to 4 weeks will cure about 70% of chronic bacterial infections of the prostate. If this treatment fails, the symptomatic manifestations of the infections can a...

Since we face the problem of rapidly growing rates of antimicrobial resistance, autovaccination may provide a treatment alternative at least in those patients which suffer from treatment refractory infections. Interest is turning towards the therapy of infectious diseases by stimulation of the immune defence mechanisms. In fact there are reports of drug resistance in a wide range of bacterial d...

The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracyclin...

Antimicrobial resistance (AMR) is a growing worldwide threat to public health due to the increase of resistant pathogens to the existing antimicrobial therapy. Common and nosocomial infections are beginning to require 2nd and 3rd line antibiotic therapy, increasing time and cost of treatment, and also contributing to the development of multidrug resistance (MDR). Natural products remain an impo...

OBJECTIVE To identify the pathogens isolated from children with acute otitis media who did not respond to antimicrobial drug therapy. METHODS Retrospective analysis of cultures obtained by tympanocentesis from 46 children. RESULTS Organisms were recovered from 34 children (74%), and 43 isolates were recovered from these individuals. The organisms were Streptococcus pneumoniae (16 isolates),...

Mastitis is the most common and economically significant disease affecting dairy cattle. A variety of bacteria can be isolated from bovine mastitis cases. and are the most common causes of contagious and environmental clinical mastitis, respectively. Antimicrobial therapy is commonly implemented for mastitis prevention and control. Unfortunately, despite the best possible antimicrobial treatmen...