A 62-year-old Japanese 'kawara' (ceramic roof tile) craftsman presented with acute kidney injury and haemoptysis. This case met the systemic lupus erythematosus and microscopic polyangiitis criteria, with high titres of myeloperoxidase-antineutrophil cytoplasmic antibody (570 EU). Results showed the presence of antinuclear antibody at a high titre (1:2560), but detection of rheumatoid factor, a...

tremity, pitting edema extending to the mid-thigh. No other abnormalities were found. Urinalysis revealed 4 proteinuria, numerous hyaline casts, and no hematuria or leukocyturia. A 24-hour urine collection contained 10 g of protein. A fasting serum chemistry panel showed severe hypoalbuminemia, 2.1 g/dL; hypercholesterolemia, 387 mg/dL; hypertriglyceridemia, 420 mg/dL; mild hyponatremia, 132 mE...

The patient was a 41-year-old woman with a 1-year history of systemic lupus erythematosus based on her discoid lupus erythematosus, photosensitivity, and her laboratory test findings that showed lymphopenia, low complement (C3, 38 mg/dL; C4, 4 mg/dL), and the presence of antinuclear antibody (1:320 speckled pattern) and antiphospholipid antibodies (anticardiolipin antibodies, anti-β2-glycoprote...

Autoimmune cholangitis (AC) is a recently proposed entity that describes a specific group of patients presenting overlapping features of primary biliary cirrhosis (PBC) and autoimmune hepatitis. The disease is characterized by dinical cholestasis, high titer antinuclear antibody, negative antimitochondrial antibody, and histologically, findings of PBC coexisting with varying degrees of parenchy...

A 24 year old woman was diagnosed with systemic lupus erythematosis (SLE) based on a few months’ history of a photosensitive skin rash, predominantly on her face, arthralgia involving both hands and wrists, a positive antinuclear antibody (ANA) test and a raised antinative double stranded DNA antibody binding level. She was treated with oral hydroxychloroquine 400 mg daily and short courses of ...

We report an asymptomatic mother of a cutaneous neonatal lupus child was diagnosed with Sjögren's syndrome suspected after parturition. A 30-year old woman was visited our hospital to evaluated autoimmune disease because her baby was diagnosed as cutaneous neonatal lupus. Both gum test and Schirmer's test were positive. Antinuclear antibody, anti-SS-A and anti-SS-B antibody were positive. Serum...

Sera from 36 patients with active chronic hepatitis were studied for the presence of antibodies to double-stranded (native) DNA. These antibodies are a specific antinuclear antibody previously shown to have a high degree of specificity for systemic lupus erythematosus. Fifteen of the 36 patients (42%) were found to have levels of antibody usually only reported in systemic lupus erythematosus an...

Serial clinical and serological observations were made on a patient with necrotising polyarteritis associated with rheumatoid arthritis. Significant levels of circulating immune complexes, as determined by a C1q binding assay, were observed up to 2 years before the clinical manifestations of polyarteritis but rose abrumptly immediately before and concurrently with the onset of polyarteritis. Co...

We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluoresc...

Table. Laboratory Data Leukocytes (× 10 6.2 Neutrophils (× 10 4.5 Eosinophils (× 10 0.1 Basophils (× 10 0 Monocytes (× 10 0.7 Lymphocytes (× 10 1 Hemoglobin (g/dL 6.9 Platelets (× 10 21.8 CRP (mg/dL 5.52 ESR (mm/h >150 BUN (mg/dL 19 Creatinine (mg/d 0.89 AST (mU/m 10 ALT (mU/m 3 LDH (mU/ 112 Antinuclear antibody (Anti-CCP antibody (Rheumatoid factor (CRP: C-reactive protein, ESR: erythrocyte se...