There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against different species with a single unify model is a goal of the major importance. In so doing, we use Marko...

Leishmaniasis is considered one of the most untreated tropical diseases in world. In this study, we investigated vitro leishmanicidal activity and cytotoxicity various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric (3), salazinic (4), galbinic (5), parietin (6), some semi-synthetic imine derivatives (7, 8, 9) (10, 11, 12, 13). Imine condensation reactions with h...