Earlier findings reported the anticancer-mediated activities of curcumin-modified compounds Pentagamavunone-1 (PGV-1) and Chemoprevention Curcumin Analog 1.1 (CCA-1.1) with several mechanisms including cell cycle arrest, reactive oxygen species (ROS) production, migration disruption. Our study aims to evaluate antimigratory activity PGV-1 CCA-1.1 on aggressive breast cancer lines (MDA-MB-231 HC...

We evaluated the in vitro antiproliferative and apoptotic potential of the ethyl acetate extract (EAE) of Peltophorum africanum, a member of the family Fabaceae (Sond) in order to validate its pharmacological use. Antiproliferation of human breast (MCF-7), colon (HT-29) and cervical (HeLa) cancer cell lines by EAE was investigated using the Cell Titer-Blue viability assay and the mechanism of a...

We evaluated the in vitro antiproliferative and apoptotic potential of the ethyl acetate extract (EAE) of Peltophorum africanum, a member of the family Fabaceae (Sond) in order to validate its pharmacological use. Antiproliferation of human breast (MCF-7), colon (HT-29) and cervical (HeLa) cancer cell lines by EAE was investigated using the Cell Titer-Blue viability assay and the mechanism of a...

Purpose Cardamonin inhibits the proliferation of SKOV3 cells by suppressing the mammalian target of rapamycin complex 1 (mTORC1). However, the mechanism of cardamonin on mTORC1 inhibition has not been well demonstrated. The regulatory-associated protein of TOR (Raptor) is an essential component of mTORC1. Here, we investigated the role of Raptor in the mTORC1 inhibition effect of cardamonin in ...

Calebin-A is a curcuminoid compound isolated from turmeric. Herein, we investigated the antiproliferative effect of calebin-A liposomes on cell growth compared with calebin-A. In this study, the calebin-A liposomes were successfully prepared by thin film-sonication method. The antiproliferative activity was evaluated in mouse neuroblastoma Neuro-2a cells and human SW480 colorectal tumor cells. ...

The constitutive expression or overactivation of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes results in aberrant metabolism arachidonic acid poor prognosis melanoma. Our aim is to compare the vitro effects selective COX-1 (acetylsalicylic acid), COX-2 (meloxicam), 5-LOX (MK-886 AA-861), 12-LOX (baicalein) 15-LOX (PD-146176) inhibition terms proliferation (SRB assay), mitochondrial viabi...