BACKGROUND Universal multi drug antiretroviral treatment in pregnancy is a global priority in our bid to eliminate paediatric HIV infections although few studies have documented the impact of antiretroviral coverage on overall pregnancy outcomes. METHODS We conducted a maternity audit at a large regional hospital in South Africa during July-December 2011 and January-June 2014 with an aim to d...

BACKGROUND Identifying factors associated with mortality for HIV-infected patients with persistent viraemia despite antiretroviral (ARV) therapy may inform diagnostic and treatment strategies. METHODS We analysed data from viraemic triple-ARV-class-experienced HIV Outpatient Study patients seen during 1 January 1999 to 31 December 2012 who, despite treatment that included ARVs from three majo...

A descriptive study was conducted on HIV patients who had started antiretroviral therapy (ART). This included a sample of 321 selected from the cohort HIV-infected followed at Medical Center for Follow-up Blood Donors (CMSDS) Abidjan (RCI), in period 2005 to 2012. These were regularly treated, according their status, with seven (07) ARV therapeutic combinations which are AZT-3TC-EFV AZT-3TC-NVP...

OBJECTIVES South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and prote...

BACKGROUND Religion shapes everyday beliefs and activities, but few studies have examined its associations with attitudes about HIV. This exploratory study in Tanzania probed associations between religious beliefs and HIV stigma, disclosure, and attitudes toward antiretroviral (ARV) treatment. METHODS A self-administered survey was distributed to a convenience sample of parishioners (n = 438)...

The antiretroviral therapy is a lifelong use of combination three or more drugs (ARVDs). One the factors contributing to significant decrease in patients’ adherence treatment high toxicity ARVs. aim study safety retrospectively and based on spontaneous reports about adverse drug reactions (ADRs) inputted ARCADe database. Materials method. objects our research were 649 messages ARVDs recorded re...

Drug-induced liver injury (DILI) is a known adverse effect of both anti-tuberculosis (anti-TB) and antiretroviral (ARV) drugs. Recent studies highlight the implications of genetic predispositions to DILI. We performed a case-control study to identify Human Leukocyte Antigen-B (HLA-B) variant alleles associated with anti-TB and ARV co-treatment induced liver toxicity in Ethiopian TB and HIV co-i...

While the prevalence of X4-tropic viruses in subtype B is relatively well studied the distribution of tropism in CRF06_cpx (causing Estonian epidemic) is less known, especially in the treatment experienced patients with established multidrug-resistance and who are candidates for therapy with CCR5 antagonist. Aim: to describe HIV-1 drug resistance mutations (DRMs) and co-receptor tropism in anti...

To read more about this study, go to the full report, http://www.popcouncil.org/pdfs/horizons/sapedssa.pdf A rapid situational analysis of the antiretroviral (ARV) rollout in South Africa found that several ARV programs are treating children successfully. However, all institutions surveyed identified a large number of concerns and challenges that need to be overcome in order to improve care for...

The shift from a country by country approach in price negotiations to a sub-regional approach has resulted in a rapid decrease in HIV/AIDS Antiretroviral (ARV) prices in Latin America and the Caribbean. Through the regional Accelerated Access Initiative in the Caribbean and Central America, ARV costs have been reduced to US$ 1,100 – US$ 1,600 per year per patient. The development however of an ...