An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), su...

A series of novel bis 1,2,3-triazole derivatives 2-Hydroxyquinoline-4-carboxylate, exhibiting diverse molecular structures were synthesized through a click reaction, incorporating combination moieties and quinoline nucleus. In vitro biological studies conducted to evaluate their antitubercular, antibacterial antifungal activities. To explore the behavioural selective properties molecules, exper...

Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2-a]pyridine-3-carboxyamides. Zolpidem was found to have antituberculosis activity (MIC of 10-50 μM) when screened against re...

UNLABELLED BACKGROUND Aminoquinoline/steroid conjugates were synthesized based on the fact that steroid transporters have been shown to accept and carry a variety of drugs. So, in continuing our research of antileishmanial and antitubercular drugs, aminoquinoline/steroid conjugates (12, 13, and 14) were regioselectively synthesized via 1, 3-dipolar cycloaddition of alkynes 3, 5, and 7 with a...

Pulmonary tuberculosis remains the commonest form of this disease and the development of methods for delivering antitubercular drugs directly to the lungs via the respiratory route is a rational therapeutic goal. The obvious advantages of inhaled therapy include direct drug delivery to the diseased organ, targeting to alveolar macrophages harbouring the mycobacteria, reduced risk of systemic to...

The aim of this study was to evaluate the sensitivity and specificity of a whole blood interferon-γ release assay, the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in the diagnosis of Mycobacterium tuberculosis (MTB) infection, and to assess its monitoring role during antitubercular treatment. In total, 20 patients received the QFT test, along with other commonly-used tests, prior to, and follo...

In search of new active molecules, a small focused library 1,2,3-triazoles derived from naphthols were efficiently prepared via the click chemistry approach. The synthesized triazole derivatives evaluated for their antifungal, antioxidant and antitubercular activities. Furthermore, to rationalize observed biological activity data, molecular docking study has also been carried out against site c...

Gramicidin S (GS) is a cyclic cationic antimicrobial peptide (CAP) with a wide spectrum of antibiotic activities whose usage has been limited to topical applications owing to its cytotoxic side effects. We have synthesized tetrahydrofuran amino acid (Taa)-containing GS analogues, and we have carried out conformational analysis and explored their structure activity relationships by evaluating th...

tuberculosis of the foot is an uncommon entity and the reported incidence is 0.1% to 0.3%. the isolated tuberculosis of talonavicular joint is exceptionally rare. in tuberculosis of the foot and ankle, the presentation is usually nonspecific. the diagnosis of tuberculosis affecting foot is difficult, especially when it is isolated. in doubtful cases, diagnosis should be confirmed by histopathol...