INTRODUCTION Isolated primary tubercular abscess is one of the rare forms of extrapulmonary tuberculosis. A greater awareness of this rare clinical entity may help in commencing specific evidence-based therapy quickly and preventing undue morbidity and mortality. CASE PRESENTATION A 30-year-old man, of Asian origin, developed a hepatic tubercular abscess which was not associated with any pulm...

Infliximab therapy is associated with higher rates of active tuberculosis (TB), particularly extrapulmonary and disseminated forms with unusual symptoms. We report the case of a 66-year-old man with Crohn's disease who developed TB mimicking lung cancer on imaging. He presented with cough and fever of 2 weeks' duration shortly after starting infliximab. Computed tomography of the chest revealed...

The diagnosis of tuberculous meningitis remains an enigma despite recent technologic advances, such as computerized tomography (CT), magnetic resonance imaging (MRI), and more recently, polymerase chain reaction of the cerebrospinal fluid. We report a patient with tuberculous meningitis who, when treated with appropriate antitubercular medications, made no progress in her recovery. Approximatel...

The efficacy of modern drugs in the treatment of tuberculosis of the spine has been evaluated by a personal follow-up for three to ten years. Operation on the vertebral lesion was done only for those patients with or without neural complications who failed to respond favourably to drug therapy and rest. Thus absolute indications for operation were present in only 6 per cent of cases without neu...

A 24-year-old woman had recently started antitubercular therapy with isoniazid, ethambutol and rifampicin. This therapy was discontinued 2 weeks later due to an itchy, desquamative, erythematous, papular rash, with painful crusts and excoriations, spreading from the face and hands to the rest of the body. 5 days after withdrawal of all drugs, widespread desquamation and exfoliation with predile...

STUDY OBJECTIVE The standard daily dose of rifampin in directly observed treatment of Mycobacterium tuberculosis (TB) is 600 mg, taken orally. The purpose of this study was to assess the efficacy of standard dose rifampin therapy in patients who were slow to respond to routine directly observed therapy (DOT). METHODS Patients with non-drug-resistant pulmonary TB who were receiving 600 mg of o...

TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions one of the major concerns for management TB. The current study has been conducted identifying causality assessment, severity as well preventability first-line anti-tubercular agents. All diagnosed patients tuberculosis attending and chest departmen...

magnesium is an essential metal that has important roles in physiological function of the body organs. ethambutol is an oral antitubercular agent with chelating effects owing to its chemical structure. the aim of present study is to determine whether ethambutol usage can alter serum magnesium concentration in patients with pulmonary tuberculosis. sixty patients with diagnosis of pulmonary tuber...

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising compounds from marine-derived entomopathogenic fungi, reported 2000 to 2022. A comprehensive literature search was co...