We evaluated in vitro the cariogenic and erosive potential of antitussive liquid oral medications for paediatric use. Fifteen paediatric liquid antitussives were sampled. The endogenous pH was evaluated by potentiometry, titratable acidity was measured according to the method adopted by the Association of Official Analytical Chemists, total soluble solids content (TSSC) readings were performed ...

Cough is one of the commonest symptoms of respiratory tract infections and is a frequent problem encountered in general practice as well as in hospital practice. A wide range of disease processes may present with cough and definitive treatment depends on identifying the cause and diagnosis. Specific treatment of the cause should control the cough, but this may not occur in all cases and in a si...

cludes about 130 species worldwide which have been found to be rich sources of new and bioactive steroidal alkaloids. Many species of Fritillaria have traditionally been used as herbal remedies in Japanese, Turkish, Pakistani and Southeast Asian folk medicines. In China, the bulbs of many Fritillaria species (“Beimu” in Chinese) have been used as antitussive and expectorant herbs in traditional...

The aim of the present study was to investigate the voluntary suppression of cough in response to capsaicin inhalation in healthy volunteers, and to determine if the dose-response curve to capsaicin was significantly altered when volunteers were asked to suppress their cough response. The quantification of the degree of voluntary suppression of induced cough could provide a new methodology for ...

The common cold is a frequent upper respiratory tract infection caused by a number of different types of viruses. Common cold affects billions of people worldwide every year; its typical symptoms include a runny nose, nasal congestion and sneezing. Colds can also cause sore throat, cough and headache. Common cold viruses do not respond to antibiotics and there are no known cures. Although the s...

The opium alkaloid noscapine is a commonly used antitussive agent available in Europe, Asia, and South America. Although the mechanism by which it suppresses coughing is currently unknown, it is presumed to involve the central nervous system. In addition to its antitussive action, noscapine also binds to tubulin and alters microtubule dynamics in vitro and in vivo. In this study, we show that n...

The opium alkaloid noscapine is a commonly used antitussive agent available in Europe, Asia, and South America. Although the mechanism by which it suppresses coughing is currently unknown, it is presumed to involve the central nervous system. In addition to its antitussive action, noscapine also binds to tubulin and alters microtubule dynamics in vitro and in vivo. In this study, we show that n...