s | 23 forced swimming test, and antidepressant effects were attenuated by local injection of NBQX into the mPFC, indicating that both an mGlu2/3 receptor antagonist and ketamine exert the effects through AMPA receptor stimulation in the mPFC. In addition, we found that depletion of serotonin blocked antidepressant effects induced by local injection of LY341495 or ketamine into the mPFC. We als...

There is a paucity of data to support „next-step“ treatments for the many patients with anxiety disorders who remain symptomatic after initial pharmacotherapy. Because of their somewhat improved safety profile, second generation antipsychotics (SGAs) are increasingly used for the treatment of nonpsychotic anxiety. The published literature describing the efficacy of SGAs in patients with anxiety...

OBJECTIVE To evaluate efficacy of trazodone hydrochloride as an adjunctive treatment for anxiety disorders as well as treatment protocol, dose range, concurrent drug use, adverse events, and therapeutic response in dogs unresponsive to other pharmacologic agents. DESIGN Retrospective case series. ANIMALS 56 dogs with anxiety disorders treated at a referral veterinary behavior clinic. PROC...

Pediatric anxiety disorders are prevalent, chronic, and often lead to significant impaired functioning that impacts both short- and long-term outcomes for children and adolescents. Treatment options include pharmacotherapy and psychosocial interventions. This presentation will review treatment advances specifically for pharmacotherapy. Current research supports serotonin reuptake inhibitors as ...

Abstract The study examined whether complementary therapy using robotic companions as social agents reduced pain and emotional anxiety in pediatric patients. A total of 18 patients, aged 6-16, and 18 parents participated in the study. The study explored whether the use of robotic animals as companion animals could reduce pain and emotional anxiety in patients and their parents. The study identi...

s | 23 forced swimming test, and antidepressant effects were attenuated by local injection of NBQX into the mPFC, indicating that both an mGlu2/3 receptor antagonist and ketamine exert the effects through AMPA receptor stimulation in the mPFC. In addition, we found that depletion of serotonin blocked antidepressant effects induced by local injection of LY341495 or ketamine into the mPFC. We als...

INTRODUCTION During the last two decades, pharmacotherapy with pyschoactive drugs has been increasingly recognised as most effective in the management of anxiety, stress and psychosomatic disorders. The continuous use of tranquillizers and psychotropic drugs may lead to a variety of autonomic, endocrine, allergic, haematopoietic and neurologic side-effects. Elevation or depression of mood is an...

The strong situation, as formulated by social psychologists, refers to an experimental condition offering unambiguous stimuli predicting or constituting hedonically strong events that uniformly guide response sets across individuals. In relation to fear and anxiety, the strong situation results from the unambiguous threat of an imminent and dangerous stimulus that evokes the adaptive fear respo...

OBJECTIVE To evaluate the use of a therapeutic regimen to treat attention deficit hyperactivity disorder patients. METHODS A total of 140 patients initially underwent physical, neurological and laboratory evaluation. Thereafter, treatment was initiated with a compounding product consisting of a tricyclic antidepressant and an anxiolytic. RESULTS The response was positive in 71.43% of patien...

[This corrects the article DOI: 10.1371/journal.pone.0158779.].