Alternative polyadenylation (APA) is a post-transcriptional mechanism to generate diverse mRNA transcripts with different 3'UTRs from the same gene. In this study, we systematically searched for the APA events with differential expression in public mouse microarray data. Hundreds of genes with over-represented differential APA events and the corresponding experiments were identified. We further...

This paper extends the recently introduced variable step-size (VSS) approach to the family of adaptive filter algorithms. This method uses prior knowledge of the channel impulse response statistic. Accordingly, optimal stepsize vector is obtained by minimizing the mean-square deviation (MSD). The presented algorithms are the VSS affine projection algorithm (VSS-APA), the VSS selective partial u...

This study describes amended parallel analysis (APA), a novel method for model selection in unsupervised learning problems such as information retrieval (IR). At issue is the selection of k, the number of dimensions retained under latent semantic indexing (LSI). APA is an elaboration of Horn’s parallel analysis, which advocates retaining eigenvalues larger than those that we would expect under ...

We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/...

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In September 1999, the American Psychological Association (APA) notified its 600 (at the time) Continuing Education (CE) sponsors that they may not offer APA CE credit to psychologists for courses on Thought Field Therapy (Murray, 1999). The controversial ruling, which was applied to all courses that purportedly influence the body’s “energy fields” by stimulating acupuncture points or using rel...

Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene regulation. Factors controlling APA are largely unknown. We developed a reporter-based RNAi screen for APA and identified PABPN1 as a regulator of this process. Genome-wide analysis of APA in human cells showed that loss of PABPN1 resulted in extensive 3' untranslated region shortening. Messenger RNA transc...

Distribution of rational points of bounded height on equivariant compactifications of PGL 2 I Takloo-Bighash, Ramin; Tanimoto, Sho Published in: Research in Number Theory DOI: 10.1007/s40993-016-0037-7 Publication date: 2016 Document Version Publisher's PDF, also known as Version of record Citation for published version (APA): Takloo-Bighash, R., & Tanimoto, S. (2016). Distribution of rational ...