In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

Electronic Health Records (EHR) offer patients the opportunity to access their own medical records. Google and Microsoft recently extended their public services by introducing internet-based personal healthcare information platforms – Google Health and Microsoft HealthVault. Over one hundred thousand people have registered at the two services since they were launched. Both companies invite othe...

We present the OWL API, a high level Application Programming Interface (API) for working with OWL ontologies. The OWL API is closely aligned with the OWL 2 structural specification. It supports parsing and rendering in the syntaxes defined in the W3C specification (Functional Syntax, RDF/XML, OWL/XML and the Manchester OWL Syntax); manipulation of ontological structures; and the use of reasonin...

Software developers often need to port applications written for a source platform to a target platform. One of the key tasks here is to find matching API calls in the target platform for the given API calls in the source platform. This task involves exhaustive reading in target platform API (Application Programming Interface) documentation to identify API methods corresponding to the given API ...

In this review article, many aspects of high-temperature hydrogen attack steel are examined in a practical, topic-based format similar to that API RP 571. This article is result reviewing over 220 articles on the subject, published mostly between 1938 and 2020, while some them were already citing research going back late nineteenth early twentieth centuries. The paper not only examines historic...

Api SI and Api SII are serine proteases of the honeybee venom containing allergenic determinants. Each protease consists of two structural modules: an N-terminal CUB (Api SI) or a clip domain (Api SII) and a C-terminal serine protease-like (SPL) domain. Both domains are connected with a linker peptide. The knowledge about the structure and function of Api SI and Api SII is limited mainly to the...

Flavonoids are polyphenolic compounds that are ubiquitous in plants and have biological effects on cancer cells and other cell types. In particular, apigenin (API) has been shown to bind to estrogen receptors, which affect the development, maturation, function, and plasticity of the nervous system. The aim of this study was to investigate the effects of 4?,5,7trihydroxyflavone (API) upon the ne...

BACKGROUND Characterization of IgE-binding epitopes of allergens and determination of their patient-specific relevance is crucial for the diagnosis and treatment of allergy. OBJECTIVE We sought to assess the contribution of specific surface areas of the major birch pollen allergen Bet v 1.0101 to binding IgE of individual patients. METHODS Four distinct areas of Bet v 1 representing in tota...