flavonoids are wide range of phytochemical with various pharmacological effects including antioxidant, anti-inflammation, anti-platelet, anti-allergic, cytotoxicity, reduce risk for heart disease or cancer etc. these flavonoids inhibited various enzymes such as prostaglandin synthase, lypoxygenase, cyclooxygenase, and induced detoxifying enzyme systems such as glutathione s-transferase. flavono...

background and objectives: the genus verbascum, with nearly 360 species, is one of the largest members of schrophulariacea family. in the flora of iran, the genus verbascum is represented by 43 species among them seventeen plants are endemic. verbascum species are well known in folk medicine and are widely used for therapeutic purposes. verbascum sublobatum murb. grows wildly in north of iran. ...

Myocytes power the movement of all organs in body. Damage to and degradation myocytes causes hypokinesia muscle-related degenerative diseases. Apigenin, a kind flavone, is being used treat many disorders. It exerts host different pharmacological activities, such as anti-inflammatory, anti-mutagenic, cardioprotective, antioxidant effects. Accordingly, apigenin considered promising candidate for ...

high performance liquid chromatography coupled with photodiode array detector (hplc-dad) has been reported to quantify isolated flavonoids or these compounds in complex biological matrices, such as chinese herbal drugs and products from factories. this work was designed, therefore, to develop an hplc-dad system to separate quercetin, luteolin and apigenin and to quantify them in extractive solu...

A phytochemical investigation of the flowers and leaves of Ficaria verna Huds. (Ranunculaceae) yielded four additional known flavonoid compounds including: kaempferol 3-O-beta-D-(6"-a-L-rhamnopyranosyl)-glucopyranoside (nicotiflorin), apigenin 8-C-beta-D-glucopyranoside (vitexin), luteolin 8-C-beta-D-glucopyranoside (orientin) and apigenin 8-C-beta-D-(2"-O-beta-D-glucopyranosyl)-glucopyranoside...

A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-gl...

The purpose of this study was to determine the importance of intestinal disposition in the first-pass metabolism of flavonoids. A four-site perfused rat intestinal model, rat liver and intestinal microsomes, Caco-2 cell microsomes, and the Caco-2 cell culture model were used. In the four-site model, approximately 28% of perfused aglycones are absorbed (approximately 450 nmol/30 min). Both absor...

High performance liquid chromatography coupled with photodiode array detector (HPLC-DAD) has been reported to quantify isolated flavonoids or these compounds in complex biological matrices, such as Chinese herbal drugs and products from factories. This work was designed, therefore, to develop an HPLC-DAD system to separate quercetin, luteolin and apigenin and to quantify them in extractive solu...

Stachys lavandulifolia is among the species that is used for immune disorders, applied topically, or taken orally as an herbal tea. The plant is also used for stomachache, anodyne, labor, and spasm. According to the results of a pharmacological survey, the extract of Stachys lavandulifolia from the aerial parts has shown to be effective in the improvement of patients suffering from anxiety diso...

A simple and sensitive HPLC-UV method has been developed for the simultaneous determination of quercetin, luteolin, and apigenin in rat plasma after oral administration of Matricaria chamomilla L. extract. The flow rate was set at 1.0 ml/min and the detection wavelength was kept at 350 nm. The calibration curves were linear in the range of 0.11-11.36 μg/ml for quercetin, 0.11-11.20 μg/ml for lu...