apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. caspases, a family of cysteine-dependent aspartate-directed proteases, play a critical role in the initiation and execution of apoptosis. in this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in sknmc (huma...

Purpose: To investigate the effect of resveratrol (RSV) on bortezomib (BTZ)-resistant multiple myeloma (MM) cells, and to elucidate underlying mechanism action.
 Methods: H929 cell lines were exposed BTZ for 8 months establish BTZ-resistant MM model. Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis measured using annex...

Purpose: To determine the inhibitory potential of betulinic acid on pro-survival signaling pathway in glioblastoma.Methods: Changes viabilities glioma cells and primary astrocytes were measured using 3-(4, 5dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptotic changes analyzed Hoechst 33342 staining Annexin V-FITC/PI kits. Western blotting was used for assaying protein e...

Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

Apoptosis or programmed cell death is a standard physiological mechanism. It essential to control the number of cells, balance division and death, regulate immune system, eliminate pathogen-infected cells. entailed different investigation determine related biochemical reactions such as activated caspase, Reactive Oxygen Species (ROS), Lipid Peroxidation (LPO), Evaluation Glutathione Content (GS...

Malignant glioma by surgery is difficult to completely remove, the recurrence rate high, survival period short and prognosis poor, which poses a great threat human health. This article mainly studies related process that curcumin induces cell apoptosis promoting reactive oxygen species production. In experiment, cells were processed Uppsala 87 malignant of cultured in vitro. 3-(4, 5-dimethylthi...

Apoptosis is a form of programmed cell death that has only recently been implicated in the pathogenesis of cardiac diseases, including ischemia and reperfusion damage and in response to cytokines and other apoptotic triggers. Methods to study apoptosis range from measures of early changes in morphology to late events such as DNA laddering. In studying apoptosis in the heart, the application of ...

Methamphetamine (Meth) is recognized as one of the most important new distributedabused drug that causes severe damage to the different parts of the brain, especiallyhippocampus. Previous studies have demonstrated that Meth can induce apoptosis and celldeath in the brain. In this study, we evaluated the long-term effects of Meth abuse in theCA1 region of postmortem hippo...

Background: Diagnostic ultrasound has been used to detect human disease especially fetus abnormalities in recent decades. Although the harmful effects of diagnostic ultrasound on human have not been established so far, several researchers showed it has had bioeffects in cell lines and in experimental animals. Three-dimensional (3D), four-dimensional (4D), and color Doppler sonography are new te...

Objective(s) Arsenic compounds are potent human carcinogen and produce a variety of stress responses in mammalian cells. Recently sodium arsenite has been recommended to be used as anti malignancy drug by American food and drug administration (FDA). In this study, we aimed to determine the apoptosis inducing effect of sodium arsenite on rat bone marrow mesenchymal stem cells exposed in vitro. ...