Traditional medicines or herbal formulations can serve as the source of potential new chemotherapeutic drugs. Nowadays novel plant derived natural products have been designed to determine biological structure-activity relationships. A new family of betulinic acid derivatives were synthesized and the structure-activity relationship of the compounds was initially evaluated by comparing their in v...

Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in colon cancer cells. Here, we show that inhibition of autophagy under serum-de...

Apoptosis signal-regulating kinase-1 (ASK-1) is an important molecule for the pro-apoptotic signaling. ASK-1 also contributes to the cellular survival for many types of cells. Thus, ASK-1 has a broad range of biological activities depending on the cell type. The present study assessed the role(s) of ASK-1 in colorectal cancer cells (HT-29) by using adenovirus vectors expressing wild-type (WT)-A...

Açaí, Euterpe oleracea Mart., is a native plant from the Amazonian and rich in several phytochemicals with anti-tumor activities. The aim was to analyze effects of açaí seed oil on colorectal adenocarcinoma (ADC) cells. In vitro analyses were performed CACO-2, HCT-116, HT-29 cell lines. strains treated for 24, 48, 72 h, viability, death, morphology analyzed. Molecular docking evaluate interacti...

Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. Murraya koenigii is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a carbazole alkaloid isolated from M. koenigii, induced apoptosis and inhibited inflammation in vitro as well as in vivo. Induction ...

Introduction and Aim: Concanavalin the lectin from Canavalia spp. share high structural similarity among same taxon exhibit wide range of biological functions. The antiproliferative activity lectins ConA (C. ensiformis), ConC cathartica), ConG gladiata) ConM rosea) were studied in human colon carcinoma. 
 Materials Methods: Human carcinoma HT-29 cells normal kidney HEK293T examined. cytoto...

Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. However, the molecular mechanism of the anti-cancer activity of Hedyotis Diffusa Willd remains unclear. In the present study, we investigated the cellular effects of the ethanol extract of Hedyotis Diffusa Willd (EEHDW) in the HT-29 human colon carc...

Phyllanthus watsonii Airy Shaw is an endemic plant found in Peninsular Malaysia. Although there are numerous reports on the anti cancer properties of other Phyllanthus species, published information on the cytotoxicity of P. watsonii are very limited. The present study was carried out with bioassay-guided fractionation approach to evaluate the cytotoxicity and apoptosis induction capability of ...

Objective(s): Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-cancer effects of EcN treatments in human colorec...

UNLABELLED 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) has been suggested as a tracer for the scintigraphic detection of multidrug resistance (MDR). The aim of this study was to compare MDR characteristics in vitro and in vivo by immunohistochemic and functional uptake assays in established tumor cell lines cultured and grown in severe combined immunodeficient (SCID) mice. METHODS The presen...