In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess copper inhibits Abeta (amyloid beta-peptide) production, but the effects of deficiency have not yet been determined. We therefore studied the effects of modulating intracellular copper levels on the processing of APP (amyloid...

Calnuc, a Golgi calcium binding protein, plays a key role in the constitution of calcium storage. Abnormal calcium homeostasis has been linked to Alzheimer's disease (AD). Excessive production and/or accumulation of beta-amyloid (Abeta) peptides that are proteolytically derived from the beta-amyloid precursor protein (APP) have been linked to the pathogenesis of AD. APP has also been indicated ...

The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention of LRP1 in the ER leads to decreased APP cell surface levels and in turn, to reduced Aβ secretion...

INTRODUCTION Previously, an app has been developed for healthcare professionals (HCPs) and patients to report adverse drug reactions (ADRs) to national medicines agencies and to receive drug safety information. OBJECTIVE This study aimed to assess (1) European HCPs' and patients' interest in an app for this two-way risk communication; (2) their preferences and perceptions towards specific app...

Mint/X11 is one of the four neuronal trafficking adaptors that interact with amyloid precursor protein (APP) and are linked with its cleavage to generate β-amyloid peptide, a key player in the pathology of Alzheimer's disease. How APP switches between adaptors at different stages of the secretory pathway is poorly understood. Here, we show that tyrosine phosphorylation of Mint1 regulates the de...

In vitro studies have shown that neuronal cell cultures secrete exosomes containing amyloid-β precursor protein (APP) and the APP-processing products, C-terminal fragments (CTFs) and amyloid-β (Aβ). We investigated the secretion of full-length APP (flAPP) and APP CTFs via the exosome secretory pathway in vivo. To this end, we developed a novel protocol designed to isolate exosomes secreted into...

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To kill a brain cell he consequences of amyloid formation by the amyloid precursor protein (APP) in Alzheimer's disease (AD) have been the focus of many studies, yet little is known about the nonpathogenic function of APP. On page 27, some progress is made in this direction by Chen et al., who show that APP induces a suicide pathway in neurons. APP initiates this death-inducing cascade when it ...

in this paper, we introduce the new notion of strongly j-clean rings associatedwith polynomial identity g(x) = 0, as a generalization of strongly j-clean rings. we denotestrongly j-clean rings associated with polynomial identity g(x) = 0 by strongly g(x)-j-cleanrings. next, we investigate some properties of strongly g(x)-j-clean.

APP is a type I transmembrane protein. Its cleavage in the amyloidogenic pathway by βand γsecretases produces the β-amyloid peptide (Aβ), the major constituent of senile plaques. In addition, the cleavage of the membrane-bound APP C-terminal fragments (CTFs) by γ-secretase releases the AICD (APP Intracellular Cterminal Domain), a soluble intracellular protein believed to control APP-dependent s...