BACKGROUND: In the era of novel antiviral drugs for treatment of chronic viral hepatitis C (HCV), the diagnosis of liver cirrhosis guides both the choice of the drug regimen, duration of treatment and subsequent follow up. Transient elastography (TE) (fibroscan) is a recent, non invasive and reliable method for the diagnosis of cirrhosis in patients with chronic HCV. We aimed at demonstrating t...

Objective: We aimed to investigate the predictive value of first-trimester aspartate aminotransferase/platelet count ratio index (APRI) and aminotransferase/alanine aminotransferase for intrahepatic cholestasis in pregnancy (ICP).
 Material Methods: The clinical data patients who admitted Obstetrics Department Umraniye Training Research Hospital, between 2015-2020 were analyzed retrospecti...

Abstract Background The liver biopsy is an essential element of evaluating progression disease in children with Progressive Familial Intrahepatic Cholestasis (PFIC) and Allagille Syndrome (AGS). Several noninvasive techniques, including radiological imaging blood biomarkers assay, can be used to evaluate stiffness. Objectives To identify whether Transient elastography (FibroScan) AST/PLT Ratio ...

BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular related death, particularly in those with hepatic fibrosis. We determined the prevalence of predicted fibrosis based on non-invasive fibrosis markers and the association of hepatic fibrosis with cardiovascular risk factors. METHODS Cross-sectional study of 575 Framingham Heart St...

BACKGROUND Noninvasive hepatic fibrosis scores that predict the presence of advanced fibrosis have been developed and validated in adult patients with NAFLD. The aims of our study were to assess the utility of commonly used adult fibrosis scores in pediatric NAFLD and to develop a pediatric specific fibrosis score that can predict advanced fibrosis. METHODS Consecutive children with biopsy-pr...

BACKGROUND Many blood tests have been proposed as alternatives to liver biopsy for identifying fibrosis or cirrhosis. PURPOSE To evaluate the diagnostic accuracy of blood tests to identify fibrosis or cirrhosis in patients with hepatitis C virus (HCV) infection. DATA SOURCES MEDLINE (1947 to January 2013), the Cochrane Library, and reference lists. STUDY SELECTION Studies that compared th...

BACKGROUND & AIMS Non-invasive diagnostic methods for liver fibrosis predict clinical outcomes in viral hepatitis and nonalcoholic fatty liver disease (NAFLD). We specifically evaluated prognostic value of non-invasive fibrosis methods in nonalcoholic steatohepatitis (NASH) against hepatic venous pressure gradient (HVPG) and liver histology. METHODS This was a retrospective cohort study of 14...

UNLABELLED No data are available about the prediction of long-term survival using repeated noninvasive tests of liver fibrosis in chronic hepatitis C (CHC). We aimed to assess the prognostic value of 3-year liver stiffness measurement (LSM), aspartate aminotransferase to platelet ratio index (APRI), and fibrosis 4 (FIB-4) evolution in CHC. CHC patients with two LSM (1,000-1,500 days interval) w...

AIM To characterize the effect of hepatic steatosis (HS) on the progression of chronic hepatitis B. METHODS A total of 162 chronic hepatitis B (CHB) patients confirmed by liver biopsy were involved in this study. All subjects were prospectively followed-up for 5 years in real-life clinical practice. Fibrosis stage was determined using aspartate aminotransferase-to-platelet ratio index (APRI)....

Although long regarded as the gold standard for liver fibrosis staging in chronic hepatitis C (CHC), liver biopsy (LB) implies both the risk of an invasive procedure and significant variability. The aim of this study was to evaluate the diagnostic performance for transient elastography (TE) and aspartate aminotransferase to platelet index (APRI) used alone and in combination compared to liver b...