Purpose To investigate the anti-inflammatory properties of ripasudil, a Rho kinase (ROCK) inhibitor, using endotoxin-induced uveitis (EIU) in rats. Methods Endotoxin-induced uveitis was induced by footpad injection of lipopolysaccharide (LPS). Ripasudil was administered intraperitoneally 1 hour before and after LPS injection. The aqueous humor was collected 24 hours after injection, and the i...

Introduction Dense non-aqueous phase liquids (or DNAPLs) are liquids that are water immiscible and at the same time are heavier than water. When a spill occurs, these liquids can migrate into aquifers and become trapped in the pores. Some techniques proved to be efficient for the recovery of DNAPLs from the aquifers. One method is the injection of fluids through injection wells, for example, co...

BACKGROUND One of the considerable uses of lettuce (Lactuca sativa) seed in traditional medicine has been to reduce semen, sperm and sexuality. OBJECTIVE The aim of this study was to investigate the effects of aqueous and hydro-alcoholic extracts of lettuce seed on testosterone level and spermatogenesis. MATERIALS AND METHODS In this experimental study 24 adult male NMRI mice weighing 20-25...

Intravenous injection into rabbits and cats of an aqueous extract of hornet venom sac, produced a significant reduction in the intraocular pressure. The mean reduction of the ocular pressure was between 7 and 15 mm Hg within one hour past injection and it lasted 6-12 h or in several instances even more than 24 h. The effect is produced by some thermolabile high-molecular-weight fraction(s), is ...

PURPOSE We sought to better characterize the intravitreal profile of different triamcinolone formulations. METHODS The study was performed in vitro and in vivo. Kenalog-40, Triesence, and Transton were characterized for ocular pharmacokinetics, particle size, crystallinity, and dissolving kinetics in vitreous following an intravitreal injection into 12 rabbit eyes. The relationship of free dr...

effect of adding melissa officinalis aqueous extract was studied on immune response and performance in 200 ross 308 broiler chicks in a completely randomized design with five treatments and four replicates and 10 observations per replicate. the amounts of 0 (control), 0.5, 1, 1.5 and 2 ml/l lemon balm extract were added in drinking water for 42 days. humoral immunity was evaluated by injection ...

PURPOSE Interleukin-6 (IL-6) has been strongly implicated in anterior uveitis based on its presence in aqueous humor from infected eyes and its inflammatory effects when injected intravitreally into rats. We used IL-6-deficient mice to test further the hypothesis that IL-6 contributes to the development of endotoxin-induced uveitis. METHODS Uveitis was scored by histologic analysis of C3H/HeN...

The aim of this study has been to visualize the aqueous outflow system in patients affected by primary open angle glaucoma. A solution of indocyanine green (ICG) plus high viscosity viscoelastic solution was injected into the Schlemm canal during surgery in 10 glaucomatous patients undergoing canaloplasty. Soon after injection of the dye the borders of the scleral flap were completely stained d...

PURPOSE Transforming growth factor beta-1 (TGF beta-1) can modulate inflammation. Endotoxin-induced uveitis (EIU) is characterized by acute ocular inflammation related to the release of cytokines, including interleukin (IL)-6. The authors investigated the effect of TGF beta-1 on EIU in mice. METHODS Three independent experiments were performed. Endotoxin-induced uveitis was induced in C3H/HeN...

Photoacoustic imaging (PA imaging or PAI) has shown great promise in the detection and monitoring of cancer. Although nanocarrier-based contrast agents have been studied for use in PAI, small molecule contrast agents are required due to their ease of preparation, costeffectiveness, and low toxicity. Here, we evaluated the usefulness of a novel cyanine dye IC7-1-Bu as a PAI contrast agent withou...