Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechanism underlying such modulation remains elusive. We explored multiple kinases b...

It is well-established that during goal-directed motor tasks, patients with essential tremor have increased oscillations in the 0-3 and 3-8 Hz bands. It remains unclear if these increased oscillations relate to activity in specific brain regions. This study used task-based functional magnetic resonance imaging to compare the brain activity associated with oscillations in grip force output betwe...

Normal human consciousness may be impaired by two possible routes: direct reduced function in widespread cortical regions or indirect disruption of subcortical activating systems. The route through which temporal lobe limbic seizures impair consciousness is not known. We recently developed an animal model that, like human limbic seizures, exhibits neocortical deactivation including cortical slo...

In this paper we consider the problem of localizing inputs in swing dynamic models of large power system networks in the form of forced oscillations with unknown amplitude and frequency. Such harmonic oscillations commonly result from internal failures of control actuators in synchronous machines, and are particularly dangerous because their frequency often lies in the range of the inter-area o...

The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thus investigated the potential release and role of the purines during GI mGluR-i...

Power system is a highly interconnected nonlinear system that needs optimal and accurate control for continuous operation. Large power transfer through long transmission line between different electrical areas, stressed system and adverse interaction between local controllers, may give rise to slow frequency inter-area oscillations. The inter-area modes may not be visible from local measurement...

Abstract Inter-area oscillations are, by far, the most detrimental oscillation category to integrity of synchronously interconnected power systems. are characterized inherent weak damping. The poor damping associated with inter-area leaves open wide probabilities for irrevocable widespread blackouts consequent eventual devastating outcomes measured in terms huge economic casualties and possible...