Indoles are converted into α-carbolines in four steps by acylation at C-3, Boc-protection, olefination of the resulting 3-indolyl aldehydes or ketones to give N-Boc-3-indolyl alkenyl oxime O-methyl ethers, which upon heating to 240 °C under microwave irradiation undergo loss of the Boc-group, and 6π-electrocyclization to α-carbolines, following aromatization by loss of methanol (11 examples, 30...

The title compound, C(18)H(17)NO(4), was obtained accidentally through acid-catalysed aromatization of a phthalimide-substituted 2-(1-hy-droxy-eth-yl)cyclo-hex-2-enone. It exhibits an intra-molecular O-H⋯O(c) (c = carbonyl) hydrogen bond and forms a three-dimensional network structure via π-π stacking inter-actions between adjacent benzene rings (phthalimide-to-phenyl-ene and phthalimide-to-pht...

We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl(3) is found to result in a mixture of imidazolinium and imidazolium salts. However, the addition of benzoic acid suppresses aromatization, a...

Bio-based furanics can be aromatized efficiently by sequential Diels-Alder (DA) addition and hydrogenation steps followed by tandem catalytic aromatization. With a combination of zeolite H-Y and Pd/C, the hydrogenated DA adduct of 2-methylfuran and maleic anhydride can thus be aromatized in the liquid phase and, to a certain extent, decarboxylated to give high yields of the aromatic products 3-...

The early steps in the biosynthesis of the aromatic amino acids in microorganisms leading to the formation of alicyclic precursors are rather well known (1, 2). Information regarding the regulation of these steps is beginning to accumulate (3, 4). A considerable gap, however, still exists in our knowledge about the properties and the regulation of the enzymes involved in the final aromatization...

In the initial papers reporting the thermal instability of chemically bonded stationary phases on irradiation with a high-power neodymium laser, Raman scattering intensity in the region 2285 to 1130 cm was found to depend on the density of coverage of the silica matrix with alkyl ligands. Further research focused on the dependence of the growth of UV absorption in this region, on heating of the...

Testosterone is aromatized to estradiol in both peripheral tissues and the central nervous system. Various authors have suggested that this conversion in the male may be prerequisite for the regulation of gonadotropin secretion by testosterone. Previously, it was reported that inhibition of central nervous system aromatase caused a significant increase in plasma LH in the presence of physiologi...

The key building block of our flexible approach to the modular synthesis substituted cycloparaphenylenes (CPPs) is in spotlight. From this stage, depicted [8]- and [10]CPPs were synthesised two more steps, macrocyclization reductive aromatization. optoelectronic properties these nanorings compared those parent CPPs, as well tube-like solid state structure. More information can be found Research...

Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization patterns that are crucial for polyketide bioactivity. The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides. The two most com...