We analyzed the clinical profiles and autopsy findings of five patients who died shortly after developing cerebral infarction following thrombotic occlusion of the internal carotid artery. In all five cases, thrombotic occlusion was caused by rupture of the fibrous lining over the gruel of atheroma at the origin of the internal carotid artery showing tight stenosis of the lumen. The mean±SD sho...

Content/Summary Low pulsatile or non-pulsatile cerebral perfusion was noted in patients with aortic arch dissection, acute proximal internal carotid or common carotid artery occlusion and means impending large cerebral infarction. A 45-year-old man had a sudden aphasia and left hemispheric symptoms with NIHSS of 16 on arrival. Complete occlusion of left middle artery with leptomeningeal collate...

Background. Patients with acute ischemic right ventricular dysfunction often develop hemodynamic compromise, yet most manifest spontaneous early clinical improvement and later recovery of global right ventricular performance. This study was designed to delineate the determinants of right ventricular performance following chronic right coronary artery occlusion. Methods and Results. Thrombotic r...

BACKGROUND Distal superior cerebellar artery (SCA) aneurysms are rare and treated using various treatment strategies. Treatment often requires parent occlusion, which raises concerns regarding the potential risk of ischemia in distal territory. OBSERVATIONS An 81-year-old woman presented with subarachnoid hemorrhage. Diagnostic cerebral angiography revealed two tiny SCA aneurysms. Because signi...

A 64-year-old Chinese man presented to the Accident and Emergency Department with chest pain and was found to be in cardiogenic shock. The electrocardiogram (ECG) showed features of acute myocardial infarction due to left main coronary artery occlusion,which had no ST elevation in precordial leads. Emergency coronary angiogram revealed left main coronary artery complete occlusion. Percutaneous ...

Spontaneous coronary artery dissection is rare and usually affects younger women in the peripartum period. Here, we report an interesting case of a 34-year-old woman with spontaneous coronary artery dissection that occurred 1 month after childbirth. Emergency coronary angiography showed stenosis of the left anterior descending artery, but immediately afterwards, a new occlusion of the right cor...

Arachidonic acid metabolites have been implicated in the development of cerebral edema following ischemia. To define the time course of metabolite production, subtemporal craniectomies were performed on 60 male Sprague-Dawley rats (350-400 g). Thirty rats underwent middle cerebral artery occlusion while 30 rats underwent craniectomy alone. Five rats in each of two groups (middle cerebral artery...

BACKGROUND AND PURPOSE Diabetes mellitus may impair endothelium-dependent responses in cerebral arterioles. The basilar artery dilates in response to increases in blood flow. The goal of this study was to examine effects of diabetes mellitus on "flow-mediated" and endothelium-dependent dilatation of the basilar artery. METHODS Diabetes was induced in rats with 50 mg/kg streptozotocin. Six mon...

BACKGROUND AND PURPOSE Prior to their relatively recent FDA approval, detachable balloons for endovascular arterial occlusion had been available on only a limited basis. We evaluated the feasibility of permanent endovascular carotid and vertebral artery occlusion using microcoils deployed with and without proximal flow arrest in 19 patients. METHODS Permanent endovascular occlusion was perfor...