The experience of acute pain serves a crucial biological purpose: it alerts a living organism to environmental dangers, inducing behavioural responses which protect the organism from further damage. In contrast, chronic pain arising from disease states and/or pathological functioning of the nervous system offers no advantage and may be debilitating to those afflicted. Despite recent advances in...

In view of the well-established anti-inflammatory properties of latex of Calotropis procera (DL), the present study was carried out to evaluate the protective effect of its methanol extract (MeDL) against inflammation and oxidative stress in monoarthritis induced by Freund's complete adjuvant (FCA) in rats. Intra-articular injection of FCA produced inflammation of the joint with a peak effect o...

The anti-arthritic effects of epoxyquinomicins on type II collagen-induced arthritis in DBA/1J mice were examined. Prophylactic treatment with epoxyquinomicins A, B, C and D (1-4 mg/kg) had potent inhibitory effects on type II collagen-induced arthritis. In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), epoxyquinomicin C (1-30 mg/kg) had neither an anti-inflammatory effect on carrag...

cortex leading to the discovery of cortisone (Mason, Myers and Kendall, 1936; Wintersteiner and Pfiffner, 1936 ; Reichstein, 1936). The beneficial effect of pregnancy on rheumatoid arthritis was first observed by Hench in 1938 but the antirheumatic arthritic action of cortisone was established as late as 1949 by Hench, Kendall and their collaborators. Since then beneficial effect of cortisone h...

Objective: The present study was designed to investigate the antiarthritic activity of methanolic stem extract of Tecoma stans in wistar albino rats using in vitro albumin denaturation method and in vivo models like complete freunds adjuvant (CFA) induced arthritis and egg albumin induced arthritic models. Acute toxicity studies were carried out and the extract was found to be safe upto 2000 mg...

Tragia involucrata commonly known as Indian stinging nettle is a shrub widely used in traditional ayurvedic system for treatment of cephalagia, skin infections, eczema, and bronchitis. However, in use as a traditional medicine since ancient time, its anti-arthritic and hemolytic properties are not yet studied. The present study aimed to assess the phytochemical analysis, in vitro anti-arthritic...