We present a simple model of experimental setup for in vitro study of drug release from drug eluting stents and drug propagation in artificial tissue samples representing blood vessels. The model is further reduced using the assumption on vastly different characteristic diffusion times in the stent coating and in the artificial tissue. The model is used to derive a relationship between the time...

Submit your manuscript here: http://www.dovepress.com/Journal-of-blood-medicine-journal The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine; Blood collection, Donor issues, Transmittable diseases, a...

Bis(2-ethylhexyl) phthalate is extracted from artificial kidneys, both in vivo and in vitro. Perfusion of whole blood through arterial-,venous tubing (that supplied with the dialyzer) for 1 h in vitro yielded 3.23 mg of the compound, while similar perfusion of the tubing plus the artificial kidney yielded 6.10 mg. Its mean concentration after dialysis in patients undergoing hemodialysis was 751...

The purpose was to investigate the effects of artificial cold air on cardiovascular risk in hypertensive subjects. An artificial cold air was simulated with hourly ambient temperature data of a real moderate cold air in China. Twenty-four male SHR rats were randomly divided into the minimum temperature (Tmin) group, the rewarming temperature (Tr) group and two concurrent control groups with six...

Neuro-nanotechnology [2] is an approach that integrates nanoparticles [3] (or nanostructures) into the field of neuroscience in order to both study the structures and functions of the brain and to treat neurological diseases. These technologies include nanoparticles [3] to deliver drugs across the blood-brain barrier, to monitor electrical signals in the brain, and to induce neural signaling in...

BACKGROUND The involvement of collateral blood flow/fluid shear stress, nitric oxide (NO), and macrophages during collateral growth (arteriogenesis) is established, but their interplay remains paradoxical. METHODS In order to further elucidate the "fluid shear stress/NO/macrophage" paradox, we investigated the time course of collateral blood flow (using a Doppler flow probe) and NOS expressio...

Over the past twenty years, DNA analysis has revolutionized forensic science, and has become a dominant tool in law enforcement. Today, DNA evidence is key to the conviction or exoneration of suspects of various types of crime, from theft to rape and murder. However, the disturbing possibility that DNA evidence can be faked has been overlooked. It turns out that standard molecular biology techn...

BACKGROUND Stationary hemodialysis machines hinder mobility and limit activities of daily life during dialysis treatments. New hemodialysis technologies are needed to improve patient autonomy and enhance quality of life. METHODS We conducted a FDA-approved human trial of a wearable artificial kidney, a miniaturized, wearable hemodialysis machine, based on dialysate-regenerating sorbent techno...