Your brain controls everything you do, and it is much more powerful than any computer can find. This complex organ sends messages using cells called neurons, never stops analyzing data, even as sleep. Scientists are trying to understand the create a digital version. But possible for computers do same things our brains can? For so, we need something an artificial neural network, which has neuron...

OBJECTIVE The main intensive care unit (ICU) goal is to avoid or reverse the organ failure process by adopting a timely intervention. Within this context, early identification of organ impairment is a key issue. The sequential organ failure assessment (SOFA) is an expert-driven score that is widely used in European ICUs to quantify organ disorder. This work proposes a complementary data-driven ...

Though artificial support systems for kidney failure have been widely available for the past several decades, it is only recently that they have become a promising treatment modality for liver failure. The various liver support systems include conventional dialysis, charcoal hemoperfusion, high volume plasma exchange, liver dialysis using sorbent technology, molecular readsorption recirculating...

The definitive treatment of patients with acute liver failure is liver transplantation. Organ Procurement and Transplantation Network status 1 patients receive priority, but the median waiting time in 2002 was 11 days. Patients who are small or have an unusual blood type are expected to wait even longer. Because cerebral edema and death may occur before a liver is available, numerous methods of...

Mechanical circulatory support has been used to treat graft failure after heart transplantation, but in patients who needed mechanical circulatory support because of chronic rejection, we have suffered from the treatment because its outcome was catastrophic. Multiple organ failure was often caused by the addition of or increase in immunosuppressive medications, and it is known as a cause of the...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 3 351–363 www.jcb.org/cgi/doi/10.1083/jcb.201407071 JCB 351 Correspondence to François Schweisguth: [email protected] Abbreviations used in this paper: APF, after puparium formation; BAC, bacterial artificial chromosome; Cad, cadherin; FRET, Forster resonance energy transfer; IQR, interquartile range; krz, kurtz; lgd, lethal(2...

Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as "organ-on-a-chip". Briefly speaking, it is a promising technology in...

onsidering the high prevalence of severe organ failures due to the cancer, congenital anomaly, or trauma, and the consequent needs for tissue transplantation, deficiencies in tissues and organs are a huge challenge for regenerative medicine at the moment. More than 40 years have passed since the term ‘tissue engineering’ was created as a new th...