introduction: hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional iron deficiency. in these patients iron therapy can be hazardous leading to hemosiderosis. recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. the aim of this study was to evaluate the effect of intravenous ascorbic acid on fu...

background functional iron deficiency (fid) may cause erythropoietin resistance in patients under hemodialysis (hd). since the role of chronic inflammation or oxidative stress in its pathogenesis is unclear, controversy remains to whether intravenous iron or intravenous ascorbic acid (an antioxidant) can improve this anemia due to decreased iron availability. objectives the current study compar...

the ameliorative activity of aqueous extract of the flesh of dates (phoenix dactylifera l.) and ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats. sixty male rats were divided into six equal groups of 10. two groups were controls, one treated with thioacetamide and one with only distilled water. two groups received extract of flesh phoenix dactylifera and intraperitoneal...

a new and simple method followed by atomic absorption spectrometry has been developedfor indirect determination of ascorbic acid (aa). the proposed method was based on the oxidationof aa to dehydroascorbic acid with cu2+cation(200mgl-1)in an ammonium thiocyanatesolution atph2.4. aa reduces cu2+to cu+followed by the precipitation of cu+ with scn-. then, the excess ofcu2+in the solution was measu...

We examined the effects of L-ascorbic acid and its analogues on DNA synthesis and cell proliferation. We also investigated the signal transduction pathways involved in the induction of mitogenesis by L-ascorbic acid and its analogues using primary cultures of adult rat hepatocytes. Following a 4-h serum-free cultivation, both L-ascorbic acid and its stable analogue, L-ascorbic acid 2-glucoside,...

BACKGROUND Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. OBJECTIVE This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir. METHODS L-ascorbic acid or its derivatives were applied to ...

Introduction: After presbycusis, noise-induced hearing loss is the second most common cause of acquired hearing loss. Numerous studies have shown that high-intensity noise exposure increases free radical species; therefore, use of antioxidants to detoxify the free radicals can prevent cellular damage in the cochlea. We studied the potential hearing protective effect of different doses of ascorb...

a simple and rapid method has been developed for the determination of ascorbic acid in fruit and pharmaceutical products. the method is based on the measurement of the reaction rate between ammonium molybdate and ascorbic acid in acidic media. the reaction was monitored spectrophotometrically at 800 nm by fixed-time and variable-time methods. the calibration graph was linear in the range of 5 0...

abstract: Ascorbic acid (Vitamin C) is an essential Vitamin which participates in many different biological processes. The ascorbic acid content in vegetables and fruits is a maturity index and its determination in such samples is of special interest in quality control. In this paper we present a titrimetric method with potassium bromide for the determination of ascorbic acid in walnut, cabbage...