Background Responses to anti-fibrotic drugs in preclinical disease models are difficult quantify by histological analysis of single tissue sections. Quantitative in-depth imaging data, termed “radiomics”, may represent a more reliable and accurate measure treatment response since the pathology whole organ is captured. Objectives To study potential µCT-derived radiomic features reflect Nintedani...

A game semantics of finite nondeterminism is proposed. In this model, a strategy may make a choice between different moves in a given situation; moreover, strategies carry extra information about their possible divergent behaviour. A Cartesian closed category is built and a model of a simple, higher-order nondeterministic imperative language is given. This model is shown to be fully abstract, w...

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A novel calcium-dependent potassium current (K slow ) that slowly activates in response to a simulated islet burst was identified recently in mouse pancreatic -cells (Göpel, S.O., T. Kanno, S. Barg, L. Eliasson, J. Galvanovskis, E. Renström, and P. Rorsman. 1999. J. Gen. Physiol. 114:759–769). K slow activation may help terminate the cyclic bursts of Ca 2 -dependent action potentials that drive...

Improving crop management inputs with remote sensing devices is an emerging technology. This study documented the progression of the normalized difference vegetative index (NDVI) during the life cycle of corn (Zea mays L.), evaluated the spatial variability of corn growth in terms of the CV (calculated from NDVI readings), and documented the relationships between NDVI, CV (calculated fromNDVI),...

ISCHEMIC HEART DISEASE is the major etiology for heart failure today (3). The initial event is frequently a large or recurrent myocardial infarction. Acute myocardial infarction starts with thrombotic occlusion of a coronary artery, develops during several hours, and terminates when necrosis has reached its ultimate extension, which is defined by the boundary of the infarct-associated vascular ...

The sensitivity of K ATP channels to high-affinity block by sulfonylureas and to stimulation by K 1 channel openers and MgADP (PCOs) is conferred by the regulatory sulfonylurea receptor (SUR) subunit, whereas ATP inhibits the channel through interaction with the inward rectifier (Kir6.2) subunit. Phosphatidylinositol 4,5bisphosphate (PIP 2 ) profoundly antagonized ATP inhibition of K ATP channe...

We have applied the perforated patch whole-cell technique to b cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials. Trains of depolarizations (to simulate glucose-induced electrical activity) resulted in the gradual (time constant: 2.3 s) development of a small ( , 0.8 nS) K 1 conductance. The current was dependent on...