The Gal/GalNAc-specific lectin on rat peritoneal macrophages (macrophage asialoglycoprotein binding protein, M-ASGP-BP) is structurally similar to rat hepatic asialoglycoprotein-binding protein (ASGP-BP) or rat hepatic lectin (RHL) and is highly homologous with the major component of RHL, RHL-1 (Ii, M, Kurata, H., Itoh, N., Yamashina, I., and Kawasaki, T. (1990) J. Biol. Chem. 265, 11295-11298)...

A new polymeric construct is proposed as a starting material for liver-targeted delivery system in the present communication. The has been designed to be sensitive pH variations and potentially loaded with hydrophobic antitumoral agents. It based on one of most used copolymers field nanomedicine: PEG-PLA. latter, usually obtained by polymerization lactic acid hydroxyl-terminated polyether, asse...