The expression of acid-sensing ion channel (ASIC) isoforms, ASIC1, ASIC2a, and ASIC3, was examined in the urinary bladder after cyclophosphamide (CYP)-induced cystitis of varying duration (4 h, 48 h, and chronic). Immunohistochemical, Western blot, and quantitative PCR approaches were used to evaluate channel expression and effects of CYP-induced cystitis in whole urinary bladder and split-blad...

The HdS (hardware dependent Software) department of A1catel Bell Antwerp, part of the Carrier Data division is responsible for the design of embedded software, firmware and off-line test software towards verification and test of ASICs, PCB-boards and complete systems. The HdS designers are interested in an executable hardware model of the system to be designed as a virtual target for debugging ...

Both FPGAs and ASICs are widely used as the technology for comparing SHA-3 hardware benchmarking process. However, the impact of target technology in SHA-3 hardware benchmark rankings has hardly been considered. A cross-platform comparison between the FPGA and ASIC results of the 14 second round SHA-3 designs demonstrates the gap between two sets of benchmarking results. In this paper we descri...

Gate arrays are often presented as a convenient means for ASIC prototyping. Obviously, they can both perform the same function and therefore be built from the same behavioral description. Design development implies a process of subsequent parameter bindings, leaving steadily less freedom for the remaining implementation choices. On the other hand, the ASIC offers more place & route freedom than...

The paper discusses the data flow and buffer management for an integrated ASIC performing the High Level Data Link Control (HDLC) protocol processing functions for large number of multi-rate (nx64Kbps) and/or sub-rate (px8Kbps) logical channels supported over time division multiplexing (TDM) network interfaces. The highly integrated ASICs are sought-out by the Original Equipment Manufacturers (...

The acid-sensing ion channels (ASICs) are a family of proton-sensing channels expressed throughout the nervous system. Their activity is linked to a variety of complex behaviors including fear, anxiety, pain, depression, learning, and memory. ASICs have also been implicated in neuronal degeneration accompanying ischemia and multiple sclerosis. As a whole, ASICs represent novel therapeutic targe...

Introduced in 1999, differential power-analysis (DPA) attacks pose a serious threat for cryptographic devices. Several countermeasures have been proposed during the last years. However, none of them leads to implementations that are provably resistant against DPA. A promising class of DPA countermeasures is masking. In this article we discuss implementations of three existing masking schemes fo...

A new high-radix systolic multiplier architecture is presented for Montgomery modular multiplication. Using a radix 2, an n-bit modular multiplication only takes about n/w+6 cycles. This leads to a competitive ASIC implementation for RSA and Elliptic Curve Cryptography (ECC).

The decision to use ASIC technology over a fullor semi-custom approach in the design of a computer system is influenced by many factors, and has a significant impact on the design methodology as well as on the completion schedule of the product. The Cray Research J90” line of 100-MHz supercomputer systems is an example of a system whose performance, cost, and schedule needs drove the designers ...

The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully characterised. The aim here was to address the hypothesis that acidic pH, similar to that found in degenerate IVDs, leads to the altered cell/functional ...