Anti-platelet agents such as aspirin and dipyridamole are main factors to prevent stroke in high-risk people. Pentoxyphiline has been reported as a red blood cell aggregation antagonist to prevent stroke. We evaluated the role of pento-xyphiline as an adjunct therapy to decrease risk of stroke in patients who were under treatment with aspirin or dipyridamole. A 5-years open labeled clinical tri...

Introduction: The prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, play critical roles in the synaptic plasticity. Therefore, long term use of COX inhibitors may impair the synaptic plasticity. Considering the wide clinical administration of aspirin and its unknown effects on information processing in the brain, the effect of aspirin and sodium salicylate on the short term synaptic p...

In order to identify the effects of vitamin A and aspirin on reducing UV lightinduced retinopathy, ERG waves were compared before and after UV light exposure in rabbits. 30 rabbits were divided into 3 groups: the first group received vitamin A, 50,000 units I.M., single dose, the second group received aspirin, 50 mg/ kg/day PO and the third group did not receive any medication. All three gr...

This study was conducted to investigate the effects of dietary influence of aspirin on growth performance, antioxidant status and mortality in the broilers subjected to cold-induced ascites. A total six hundred 1-d old male broilers (Ross, 308) were randomly allotted to four treatment groups, with five replicate pens per treatment and 30 birds each. The experimental groups were kept in a cold c...

PURPOSE Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one seco...

background: in patients with acute stroke and middle cerebral artery (mca) stenosis, microembolic signals (mes) can predict further cerebral ischemia. therefore, this study was designed to evaluate the prevalence of mes by transcranial doppler (tcd) in patients with mca stenosis under treatment of aspirin or clopidogrel. methods: a randomized clinical trial was performed on 40 patients with acu...

This study investigated the role and mechanism of aspirin combined with rehabilitation training in nerve injury repair Schwann cell changes rats sciatic injury. Totally, 120 male healthy SD were randomly divided into sham, model, aspirin, + groups, 30 each group. The function index (SFI), photothermal pain tolerance threshold inclined plane test results at 4, 6, 8 weeks after operation compared...

Fatigue is recognized as one of the most disabling and frequent symptoms of multiple sclerosis (MS). Amantadine appears to have some proven ability to alleviate the fatigue in MS. The aim of this study was to assess the efficacy of co-administration of amantadine and aspirin for the treatment of fatigue in multiple sclerosis. Forty-five ambulatory patients aged 20–50 years with a diagnosis of M...

background iodinated x-ray contrast media are the most commonly used contrast agents in the world with an annual application of 40-50 million. new non-ionic con- trast agents are subdivided into low osmolar agents such as iopromide and iso-osmolar agents such as iodixanol. regarding different biochemical characteristics, these agents are different in the allergic reactions and contrast enhancem...