Meningitis is the most serious manifestation of extrapulmonary tuberculosis. Being a paucibacillary disease, no single diagnostic test is sensitive and specific. Despite recent advances in diagnostic methods and readily available effective chemotherapy, more than 50% of the patients either die or are left with major neurological deficits due to delay in the diagnosis. HIV coinfection is associa...

Short historical data on occupational neurotoxicology, as well as on the pathogenic mechanisms of the nervous system impairments due to occupational factors are described. The main difficulties in the assessment of peripheral and central nervous system lesions are stressed.