BACKGROUND The role of the renin-angiotensin system in gastric physiology and disease has as yet been sparsely explored. The first aim of the study was to investigate the baseline presence and location of angiotensin II receptors (AT1R and AT2R) in the stomach of the Mongolian gerbil. A second aim was to elucidate whether the presence of H. pylori infection is associated with changes in the exp...

METHODS Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1...

OBJECTIVES Angiotensin II (ATII) type 1 receptor (AT1R) blocker (ARB) has been shown to inhibit neointimal formation. Bone marrow-derived mononuclear cells (BM-MNCs) give rise to smooth muscle (SM)-like cells at injured arterial wall and contribute to neointimal formation. However, role of the renin-angiotensin system in the homing process of SM-like cells during neointimal formation is unknown...

Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity. The new clusters of adipocytes that emerge with WAT browning have been named 'beige' or 'brite' adipocytes. Recent reports have indicated that the renin-angiotensin syste...

The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death. Therefore, it is important to design and synthesize compounds that affect beneficially these two receptors. Cardiovascular disease, which is a...

Ang (1-7) is generated by angiotensin-converting enzyme 2 (ACE2) from AngII,6 and has many protective effects on the cardiovascular system through its receptor.7 Shah and colleagues8 used 2-kidney 1-clip (2K1C) hypertensive rats and assigned them to either a sedentary or trained group. Chronic infusion of Ang (1-7) attenuated hypertension and cardiac hypertrophy only in the trained rats, but no...

Ang II is the major effector of the Renin–Angiotensin–Aldosterone System (RAAS). This system consists mainly of a 2-step enzymatic cascade catalyzed by renin and Angiotensin-Converting Enzyme (ACE), generating Ang II [1], the effect of Ang II is mediated by Ang II receptors. Two isoforms of Ang II receptor have been identified: type 1 receptor (AT1R) and type 2 receptor (AT2R). In general, it i...