This paper describes recent experiences with evaluating and implementing advanced internetwork communication protocols on top of ATM. First, performance results with conventional TCP/IP over ATM based on Digital Equipment’s Gigaswitch /ATM are reported. It becomes obvious that current protocols must be tuned specifically in order to exploit ATM performance. In order to address advanced quality ...

It is well documented that the eeective throughput of TCP can suuer on plain ATM networks. Several research eeorts have aimed at developing additions to ATM networks like Early Packet Discard that avoid TCP throughput degradation. This paper instead investigates improvements to TCP that allow it to perform well on ATM networks without switch-level enhancements, thus avoiding additional complexi...

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In certain hypoxic conditions, replication stress occurs in the absence of detectable DNA damage. H...

ATM (Asynchronous Transfer Mode) network is the core communication network of civil aviation aeronautical telecommunication network. So it is an urgent time to do scientific risk assessment for ATM network as soon as possible. According to threats and vulnerabilities existing in ATM network, which could bring bad influence to assets and missions of ATM network, even threaten the whole security ...

In response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here, we show that MRN-ATM also has critical functions in defending the cell against DNA viruses. We reveal temporally distinct responses to adenovirus genomes: a critical MRN-ATM DDR that must be inactivated by E1B-55K/E4-ORF3 viral oncoproteins and...

SEAN (Signaling Entity for ATM Networks) is freely distributed, object{oriented, extensible software for research and development in host ATM signaling. SEAN software is object{oriented and can be used both for simulation, experimentation, and operation. SEAN includes a complete source-level release of the host native ATM protocol stack, and implements the ATM User Network Interface, compliant ...

UV radiation induced genomic instability is one of the leading causes for melanoma. Phosphorylation of Ataxia Telangiectasia Mutated (ATM) is one of the initial events that follow DNA damage. Phospho-ATM (p-ATM) plays a key role in the activation of DNA repair and several oncogenic pathways as well as in the maintenance of genomic integrity. The present study was therefore performed to understa...

Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients show abnormalities of Ig isotype expression, we assessed the role of ATM in CSR by examining ATM-d...

T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong predisposition of AT patients to develop T-PLL and the high frequency of T-cell...

The Advanced Network Technologies is a research that investigates the technology(s) behind today’s modern networks and network infrastructures one of these technologies being Asynchronous Transfer Mode (ATM). Therefore, also focuses its attention on ATM. Dubbed “Modelling and Performance Studies of ATM Networks”; this research seeks to look at, and into, the impact of application segment length...