In the next 10 years, the pharmaceutical industry anticipates that revenue from biotherapeutics will overtake those generated from small drug molecules. Despite effectively treating a range of chronic and life-threatening diseases, the high cost of biotherapeutics limits their use. For biotherapeutic monoclonal antibodies (mAbs), an important production cost is the affinity resin used for prote...

The successful use of a microband electrode printed on silicon internal reflection element to perform time resolved infrared spectroscopy is described. Decreasing the critical dimension several hundred micrometers provides sub-microsecond constant in Kretschmann configured spectroelectrochemical cell. high brilliance synchrotron sourced radiation has been combined with specially designed horizo...

Binary water mixtures usually display a water relaxation (process II) which can be studied by broadband dielectric spectroscopy (BDS) at subzero temperatures. In a large collection of binary water mixtures, a slight increase of the relaxation strength is observed for low water concentration, whereas a faster increase is seen above a critical concentration. The assumption behind this result is t...

Nonmelanoma skin cancers represent 95% of cutaneous neoplasms. Among them, squamous cell carcinoma (SCC) is the more aggressive form and shows a pattern of possible metastatic profile. In this work, we used Fourier transform infrared spectroscopy (FTIR) spectroscopy to assess the biochemical changes in normal skin caused by squamous cell carcinoma induced by multi-stage chemical carcinogenesis ...

Acrylonitrile–Butadiene–Styrene (ABS) polymers have a complex microstructure which is formed during the grafting reaction of polybutadiene seed latex. During reaction, some styrene-acrylonitrile (SAN) chains are grafted onto (PB) backbone chains, and this critical to achieve effective dispersion compatibility both phases. Therefore, accurate characterization properties helps understanding polym...