OBJECTIVES Approximately 4% to 12% of pregnant women have asthma; few studies have examined the effects of maternal asthma medication use on birth defects. We examined whether maternal asthma medication use during early pregnancy increased the risk of selected birth defects. METHODS National Birth Defects Prevention Study data for 2853 infants with 1 or more selected birth defects (diaphragma...

INTRODUCTION Choanal atresia is a rare congenital malformation of the nasal cavity characterized by the complete obliteration of the posterior choanae. In 67% of cases choanal atresia is unilateral, affecting mainly (71%) the right nasal cavity. In contrast to the unilateral form, bilateral choanal atresia is a life-threatening condition often associated with respiratory distress with feeding a...

To reveal the molecular mechanism of selective follicular atresia in porcine ovaries, we investigated the changes in the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor (DR4) proteins and TRAIL mRNA in granulosa cells during follicular atresia. Immunohistochemical, Western immunoblotting and reverse transcription-polymerase chain reaction analyses ...

Choanal atresia is caused by failure of resorption of the bucco-pharyngeal membrane during embryonic development. The atresia can be membranous or bony in nature, but is usually mixed in most cases. When the atresia is bilateral, newborns can have severe airway distress and cyanosis is alleviated by crying. Bilateral choanal atresia is managed with an oropharyngeal airway. Flexible nasal endosc...

BACKGROUND Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may be isolated, it is more commonly reported in literature in association with other congenital anomalies. MATERIALS AND METHODS This study is a review of prospectively collected data of all the patients with colonic atresia presented to our center (Ain Shams University) during 2008 to 2016. RESULT...

OBJECTIVE To evaluate the intraoperative use of mitomycin to improve the surgical outcome and reduce the rate of soft tissue restenosis in children undergoing choanal atresia repair. DESIGN Retrospective chart review of all patients surgically treated for congenital choanal atresia by the senior author (W.F.M). SETTING Tertiary children's hospital. PATIENTS Eight consecutive patients with...

There is still disagreement concerning the precise nature of the anterior ventricular chamber in "tricuspid atresia". Some argue that it is a right ventricle, while our own previous studies have suggested it is comparable to the outlet chamber seen in classical "single ventricle". We have compared the morphology of the anterior ventricular chambers in 48 examples of tricuspid atresia (absent ri...

Introduction Jejuno-ileal atresia is the most common cause of congenital intestinal occlusion in newborns and the duodenal atresia is the most common cause of high bowel obstruction in the neonatal period. Nowadays the minimally invasive approach has been widely diffused and these surgical options are possible: circumbilical incision, the video-assisted and totally laparoscopic treatment. We pr...

Background: The management of dehiscence esophageal anastomosis is challenging and requires a multidisciplinary approach. Endoluminal vacuum therapy (EVT) has shown promising results. Case Presentation: Herein we present the data two cases with atresia who developed anastomotic leakage, during 2021-2022, underwent EVT. first case had 60% anastomosis, leak repair was performed followed by EVT pl...

VACTERL association occurs in 1 10000- 40000 live births and is associated with vertebral defects, anal atresia, cardiac malformations, tracheoesophageal fistula, renal dysplasia limb defects. A 19-week-old male foetus antenatal diagnosis of foetal hydronephrosis on ultrasound the left kidney was medically terminated brought for autopsy. No other malformation reported scan. On autopsy, facial a...