Over the years, studies have been conducted on mice to determine a link between the behaviors of mice with autism and the behavior of individuals with autism. A recent study conducted by Li-Feng Jiang-Xie et al. (2014), aimed to clarify the disturbance of synaptic balance arising from the loss of function of Dlgap2, a gene that has gained the title as a candidate gene in autism spectrum disord...

autism is a developmental disability with age of onset in childhood (under 3 years old), which is characterized by definite impairments in social interactions, abnormalities in speech, and stereotyped pattern of behaviors. due to the progress of autism in recent decades, a wide range of studies have been done to identify the etiological factors of autism. it has been found that genetic and envi...

Sentence complexity in children with autism and specific language impairment." MA (Master of Arts) thesis, iii ABSTRACT Children with high-functioning autism, children with specific language impairment, children with autism and language impairment, and controls produced sentences after a prompt to form a sentence using a specific word. The sentences were analyzed for length and syntactic comple...

OBJECTIVE To translate into Brazilian Portuguese the Autism Diagnostic Interview-Revised (ADI-R), an extremely useful diagnostic tool in autism. METHODS A case-control study was done to validate the ADI-R. After being translated, the interview was applied in a sample of 20 patients with autism and 20 patients with intellectual disability without autism, in order to obtain the initial psychome...

NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structure of bacterial NhaA and use it to screen autism-associated variants in the hu...

In this paper studies of executive function in autism spectrum disorder are reviewed. Executive function is an umbrella term for functions such as planning, working memory, impulse control, inhibition, and shifting set, as well as for the initiation and monitoring of action. In this review, the focus will be on planning, inhibition, shifting set, generativity, and action monitoring. While it is...

Prosody can be conceived as having form (auditory-perceptual characteristics) and function (pragmatic/linguistic meaning). No known studies have examined the relationship between form- and function-level prosodic skills in relation to the effects of stimulus length and/or complexity upon such abilities in autism. Research in this area is both insubstantial and inconclusive. Children with autism...

BACKGROUND Autism research has previously focused on either identifying a latent dimension or searching for subgroups. Research assessing the concurrently categorical and dimensional nature of autism is needed. AIMS To investigate the latent structure of autism and identify meaningful subgroups in a sample spanning the full spectrum of genetic vulnerability. METHOD Factor mixture models wer...

Autism spectrum disorders (ASD) have attracted public attention by its high prevalence, elevated social cost and large impact on the family [1]. Since the first descriptions of au‐ tism made by Hans Asperger in 1938 [2] and by Leo Kanner in 1943 [3, 4], much discus‐ sion has focused in the search for the triggering points of autism and identifying risk factors has become a high priority of scie...

Parents of children with autism have difficulties obtaining adequate information and support to guide them in the care of their children. However, the growth of communication technologies such as email has created greater opportunities for accessing such resources. This article presents a grounded theory analysis of the messages sent to an email group by parents of children with autism. The cor...