Weintraud (1913) was the first to envisage the possibility that tissue alterations in rheumatic patients may be due to a pathogenic anaphylactic reaction, but at that time it was not possible to verify his hypothesis by laboratory tests. The toxic properties of sera from rheumatic fever patients were first experimentally demonstrated by Ramsdell and Davidsohn (1930), and Klujeva and Bobritzkaja...

BACKGROUND Alzheimers disease (AD) has been strongly linked to an anomalous self-assembly of the amyloid-β peptide (Aβ). The correlation between clinical symptoms of AD and Aβ depositions is, however, weak. Instead small and soluble Aβ oligomers are suggested to exert the major pathological effects. In strong support of this notion, immunological targeting of Aβ oligomers in AD mice-models show...

Specificity, antibody isotype distribution and levels of natural antibodies (NAb) may be potential informative parameters for immune mediated natural disease resistance, immune modulation, and maintenance of physiological homeostasis. A large proportion of mammalian NAb have affinity for or are directed against self-antigens; so called natural auto antibodies (N(A)Ab). In the present study we s...

Recorded observations suggest strongly but not conclusively that auto-immunity is a factor in the pathogenesis of at least some forms of juvenile diabetes mellitus. This view is based on the occasional association of juvenile diabetes with Hashimoto's disease, which is a well-known example of auto-immunity, the presence of thyroid antibodies in some cases of diabetes, and the pathohistological ...

The association between thyroid autoimmunity and thyroid cancer was carried out in a series of solitary thyroid nodules submitted to fine-needle aspiration cytology and subsequent histopathology. US guided FNACs were obtained from 295 unselected consecutive patients with single thyroid nodules and positive (98) or negative (197) serum anti-thyroid antibody. Cytological results were classified i...

The stiff-person syndrome is a disorder of persistent, painful muscle contractions predominately affecting the axial musculature. We describe a patient with this disorder and review its pathophysiology. Molecular biologic and immunologic techniques have recently added to the understanding of the mechanism of this disorder. Association with diseases such as diabetes, vitiligo and hypothyroidism ...

概 要 橋 本病 をは じめ とす る各種 甲状腺疾患患者血 中に証 明 され る甲状腺 自己抗 体の意義 については 今 日ほ とん ど明 らかに され てい ない.そ こで確 実 に診断 した 甲状腺 疾患患者343例 につG,血 中甲状 腺 自己抗体 をthyroglobulin 抗原 とす る沈降反応(PT),タ ンニン酸処理血球 に よる感作血 球凝 集 反応(TRC),お よび機 能亢進症 のmicrosome分 画を抗 源 とす る補 体結舎反応(M C F)の3法 に よ り測 定 し,臨 床症状,検 速査所 見,治 療,経 過,と くに甲状腺組織所 見 と対 比せ しめ,か か る血 中抗体 の臨 床的意義 につ き検 討を加 えた.血 中抗体陽性率 は甲状襟 疾患で他種疾患,健 康者に比 しい ち じる しく高 く,甲 状腺 疾患 では慢性甲状腺炎が抗体価 ともに...