BACKGROUND Human tissue plasminogen activator (tPA) belongs to the serine protease family. It converts plasminogen into plasmin and is used clinically to treat thrombosis. Human tPA is composed of 527 amino acids residues and contains 17 disulfide bonds. Escherichia coli has been used only rarely for the efficient production of recombinant tPA. However, the functional expression of full-length ...

Introduction Auto-inflammatory syndromes are defined as conditions caused by an exaggerated innate immune system response, resulting in episodes of spontaneous inflammation affecting multiple organs. The prototypical auto-inflammatory disorders are associated with periodic febrile episodes. Auto-inflammatory syndromes now include polygenic diseases, such as Behcet’s syndrome and Still’s disease...

We report the results of an extensive experimental campaign dedicated to analysis turbulent dispersion owing circulations in tidal environments, characterized by a inlet and channel with lateral flats. focus on weakly-convergent weakly-dissipative estuaries or embankments, where internal waters communicate open sea through mouth. Tides are reproduced as single multiple harmonics waves. Particle...

BACKGROUND Appropriate treatment of osteonecrosis of femoral head (ONFH) remains challenging. OBJECTIVES Here, we report the results of treating these patients with auto-corticocancellous bone graft from iliac crest to overcome the need for early total hip arthroplasty (THA). PATIENTS AND METHODS There were 132 hips (96 patients) with ONFH. Association Research Circulation Osseous (ARCO) ty...

We study the SZ-effect-induced non-Gaussianity in the cosmic microwave background (CMB) fluctuation maps. If a CMB map is contaminated by the SZ effect of galaxies or galaxy clusters, the CMB maps should have similar non-Gaussian features as the galaxy and cluster fields. Using the WMAP data and 2MASS galaxy catalog we show that the non-Gaussianity of the 2MASS galaxies is imprinted on WMAP map...

As many as 59% of the transcription factors in Escherichia coli regulate the transcription rate of their own genes. This suggests that auto-regulation has one or more important functions. Here, one possible function is studied. Often the transcription rate of an auto-regulator is also controlled by additional transcription factors. In these cases, the way the expression of the auto-regulator re...

We report a study that examines performance of pilots flying a simulated UAV in a highfidelity environment while using different types of perfect and imperfect automation aids. Fiftysix student pilots carried out simulated UAV missions containing a 3D view of terrain, a 2D topdown navigational map, system parameter gauges, and a message box. Trajectory and manipulation of a 3D camera was contro...