Abstract Background and Aims Autosomal dominant policystic kidney disease (ADPKD) is the most common genetic disease. It caused by mutations in PKD1 PKD2 genes, which encode for polycystin-1 (PC-1) polycystin-2 (PC-2), two proteins localized primary cilia regulate calcium permeability cellular signaling pathways. The major phenotype of formation multiple cysts kidneys but many cases it also inv...

autosomal dominant polycystic kidney disease (adpkd) is the most common form of inherited kidney disease that results in renal failure. pkd currently has no causative therapy. however, some treatment options are available, ranging from symptomatic therapy to delaying the onset of end-stage renal failure. early diagnosis of adult polycystic kidney disease is vital in order to prevent its complic...