نتایج جستجو برای: axin2
تعداد نتایج: 430 فیلتر نتایج به سال:
CONTEXT Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathway seems to play a major role in ACC aggressiveness, and might, thus, represent a promising therapeutic t...
PURPOSE High mobility group (HMG) transcription factors of the T-cell-specific transcription factor/lymphoid enhancer binding factor (TCF/LEF) family are a class of intrinsic regulators that are dynamically expressed in the embryonic mouse retina. Activation of TCF/LEFs is a hallmark of the Wnt/beta-catenin pathway; however, the requirement for Wnt/beta-catenin and noncanonical Wnt signaling du...
Abstract Transcriptional regulation by Wnt signalling is primarily thought to be accomplished a complex of ?-catenin and TCF family transcription factors (TFs). Although numerous studies have suggested that additional TFs play roles in regulating target genes, their mechanisms action not been investigated detail. We characterised Wnt-responsive element (WRE) downstream the gene Axin2 found TCFs...
AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis
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