espanolEl linfoma cutaneo primario difuso de celulas B grandes tipo pierna es un agresivo que afecta en particular a pacientes del sexo femenino edad avanzada con lesiones tumorales crecimiento rapido miembros inferiores y posee pronostico desfavorable comparacion la mayor parte los linfomas cutaneos primarios B. Se presenta el caso una paciente 86 anos miembro inferior izquierdo cara, placas a...

GCET1 (germinal center B cell-expressed transcript-1) gene codes for a serpin expressed in germinal center (GC) B cells. Following the observation that follicular lymphoma cases exhibit an increased level of Gcet1 expression, compared with follicular hyperplasia, we have characterized Gcet1 protein expression in human tissues, cell lines, and a large series of lymphomas. To this end, we have pe...

At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...

Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% older adults age 40 and incidence increases with aging [2,3], MBL widely associated as one main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphoma (SLL), since studies Prospecti...

A proangiogenic micromilieu is associated with a worse prognosis in systemic lymphoma. Hence, targeting the tumour microenvironment and its vasculature has evolved as a promising novel treatment strategy. The role of tumour neoangiogenesis in cutaneous B-cell lymphoma, however, has not yet been elucidated. Therefore, we examined the expression of vascular endothelial growth factor (VEGF) and it...

BACKGROUND p53 gene mutations are associated with human tumors, and are among the most common genetic abnormalities. To understand the relationship between p53 mutations and glycine decarboxylase (GLDC) expression in B cell lymphoma, we established B cell lymphoma animal models to study GLDC expression in B cell lymphoma mice. MATERIALS AND METHODS Based on immunohistochemical staining result...

Primary small intestinal malignancies are rare and accounting for 1-2% of all gastrointestinal (GIT) tumors. Extranodal lymphomas most commonly found in GIT with majority sites stomach, intestine ileo-cecal junction. Non-Hodgkin’s Lymphoma (NHL) predominantly B cell type constituting 90% cases few T type. The purpose this editorial is to highlight the morphology rarity lymphoma encountered jeju...